FAST GREEN FCF

Overview

Chemical Names
Disodium 3-[N-ethyl-N-[4-[[4-[N-ethyl-N-(3-sulfonatobenzyl)amino]phenyl](4-hydroxy-2-sulfonatophenyl)methylene]-2,5-cyclohexadien-1-ylidene]ammoniomethyl]-benzenesulfonate
Synonyms
C.I. Food Green 3; FD and C Green No. 3
CAS number
2353-43-9
INS
143
Functional Class
Food Additives
COLOUR
INS matches
143

Evaluations

Evaluation year: 2017

ADI:
0–25 mg/kg bw

Comments:
The ADI of 0–25 mg/kg bw established previously by JECFA was based on a long-term rat dietary that identified a NOAEL of 5% Fast Green FCF (equivalent to 2500 mg/kg bw per day), the highest concentration tested. JECFA concluded that the new data that had become available since the previous evaluation gave no reason to revise the ADI and confirmed the ADI of 0–25 mg/kg bw.
Intake:
JECFA noted that the conservative dietary exposure estimate for Fast Green FCF of 12 mg/kg bw per day (95th percentile for adolescents) was below the upper bound of the ADI. JECFA concluded that dietary exposures to Fast Green FCF for adolescents and all other age groups do not present a health concern.
Meeting:
84
Specs Code:
R
Report: 
">TRS 1007-JECFA 84/24
Tox Monograph: 
FAS 75 JECFA 84/69
Specification: 
FAO JECFA Monographs 20/22

Evaluation year: 1986

ADI:
0-25 mg/kg bw
Meeting:
30
Specs Code:
R
Report: 
TRS 751-JECFA 30/24
Tox Monograph: 
FAS 20-JECFA 29/165 (1985)
Specification: 
COMPENDIUM ADDENDUM 10/FNP 52 Add.10/34 (METALS LIMITS) (2002). R; FAO JECFA Monographs 1 vol.2/49
Addendum: 
FAS 21-JECFA 30/111
Previous Years:
1986, FNP 37-JECFA 30/51. R; COMPENDIUM/639 1985, TRS 733-JECFA 29/32, FNP 34-JECFA 29/83, FAS 20-JECFA 29/165. 0-12.5 (TEMPORARY). TE. R 1984, FNP 31/1-JECFA 28/77. R,T 1981, TRS 669-JECFA 25/19, FAS 16-JECFA 25/95. 0-12.5 (TEMPORARY). TE. S 1969, N
1986, FNP 37-JECFA 30/51. R; COMPENDIUM/639 1985, TRS 733-JECFA 29/32, FNP 34-JECFA 29/83, FAS 20-JECFA 29/165. 0-12.5 (TEMPORARY). TE. R 1984, FNP 31/1-JECFA 28/77. R,T 1981, TRS 669-JECFA 25/19, FAS 16-JECFA 25/95. 0-12.5 (TEMPORARY). TE. S 1969, N