FD AND C BLUE No. 2

Overview

Chemical Names
Disodium 3-3'-dioxo-2,2'-bi-indolylidene-5-5'-disulfonate
Synonyms
Indigo Carmine; C.I. Food Blue 1; Fd and C Blue No. 2
CAS number
860-22-0 (5,5' ISOMER)
INS
132
Functional Class
Food Additives
COLOUR
INS matches
132

Evaluations

Evaluation year: 2018

ADI:
0-5 mg/kg bw

Comments:
JECFA considered the new data that had become available since the previous evaluation as well as previously evaluated studies and concluded that there are no reasons to revise the ADI and confirmed the previous ADI of 0–5 mg/kg bw.
Intake:
JECFA noted that the conservative dietary exposure estimate of 0.8 mg/kg bw per day (95th percentile for children and toddlers) is less than the upper limit of the ADI of 0–5 mg/kg bw established for indigotine. JECFA concluded that dietary exposure to indigotine for all age groups does not present a health concern.
Meeting:
86
Specs Code:
R
Report: 
">TRS 1014-JECFA 86/34
Tox Monograph: 
FAS 77 JECFA 86/161
Specification: 
FAO JECFA Monographs 22/41

Evaluation year: 1974

ADI:
0-5 mg/kg bw
Meeting:
18
Specs Code:
R (1984)
Report: 
NMRS 54/TRS 557-JECFA 18/17
Tox Monograph: 
FAS 6/NMRS 54A-JECFA 18/95
Specification: 
COMPENDIUM ADDENDUM 10/FNP 52 Add.10/34 (METALS LIMITS) (2002). R; FAO JECFA Monographs 1 vol.2/207
Previous Years:
1984, FNP 31/1-JECFA 28/95. R; COMPENDIUM/783 1981, FNP 19-JECFA 25/115. R 1974, FAS 7/NMRS 54B-JECFA 18/58. R 1969, NMRS 46/TRS 445-JECFA 13/12, FAS 70.36/NMRS 46A-JECFA 13/43. 0-2.5 (TEMPORARY). TE. S 1964, NMRS 38/TRS 309-JECFA 8/22, FAS 66.25/NMR
1984, FNP 31/1-JECFA 28/95. R; COMPENDIUM/783 1981, FNP 19-JECFA 25/115. R 1974, FAS 7/NMRS 54B-JECFA 18/58. R 1969, NMRS 46/TRS 445-JECFA 13/12, FAS 70.36/NMRS 46A-JECFA 13/43. 0-2.5 (TEMPORARY). TE. S 1964, NMRS 38/TRS 309-JECFA 8/22, FAS 66.25/NMR