Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan
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Abstract
A prospective study was carried out in an area of unstable malaria transmission in central Sudan to determine the efficacy and toxicity of quinine in pregnancy. Thirty-three pregnant women with severe Plasmodium falciparum malaria at mean 28.8 weeks gestational age were treated with quinine for 7 days. The mean body temperature on presentation for 3 patients who delivered prematurely was significantly higher than for those who delivered at term [39.2 +/- 0.7 degrees C versus 38.7 +/- 1.3 degrees C]. There were no significant difference between the 2 groups in other clinical or biochemical parameters. There were no clinically detectable congenital malformations and no auditory, visual or other neurological deficits in the babies at birth or 6 months later. Quinine may be safe in the treatment of severe falciparum malaria during pregnancyCitation
Adam, I., Mirghani, O.A., Saed, O.K., Ahmed, S.M., Mohamadani, A.A. et al. (2004). Quinine therapy in severe Plasmodium falciparum malaria during pregnancy in Sudan. EMHJ - Eastern Mediterranean Health Journal, 10 (1-2), 159-166, 2004 https://iris.who.int/handle/10665/119396