Tumour necrosis factor-alpha concentration in severely asthmatic children
Резюме
We assessed tumour necrosis factor-alpha [TNF-alpha] concentrations in 80 asthmatic children, 26 with severe asthma in early-phase reaction, 26 with severe asthma in late-phase reaction, 28 with severe asthma controlled in between attacks with oral prednisone and 20 matched control children. TNF-alpha was measured in patients' plasma and in a supernatant of lipopolysaccharide-stimulated [LPS] peripheral blood mononuclear [PBM] cells. TNF-alpha concentrations in plasma and the supernatant of LPS-stimulated cells were positively correlated and the concentration also correlated positively with the time lapse between the start of the asthma attack and the time of blood sampling. TNF-alpha concentration was significantly higher in the late-phase reaction group compared to the other groups, indicating a need to counteract its release and/or effects early in asthma patientsОписание
Massoud, M.N. (2000). Tumour necrosis factor-alpha concentration in severely asthmatic children. EMHJ - Eastern Mediterranean Health Journal, 6 (2-3), 432-436, 2000 https://iris.who.int/handle/10665/118888