Title of the centre:
WHO Collaborating Centre for the monitoring of anthelminthic drug efficacy for soil-transmitted helminthiasis
Director / Head:
Dr Jozef Vercruysse
Department of Virology, Parasitology & Immunology. Laboratory for Parasitology.
Faculty of Veterinary Medicine, Salisburylaan 133
Date of Designation:
Terms of Reference:
- To provide a yearly report to WHO that includes e.g.: (1) summary of the published literature related to the efficacy of anthelmintics and/or anthelmintic resistance (AR) for Soil Transmitted Helminths (STH), (2) results of studies initiated by the CC on the monitoring of efficacy of anthelmintics, (3) updating on new techniques becoming available of operational guidelines for the monitoring of drug efficacy.
- To provide technical advice to WHO in the field of anthelmintic drug efficacy.
- To identify/select world–wide (new) study sites able to assess efficacy of anthelmintics for STH using as criteria: (1) The ability of the sites to perform the studies e.g. presence of equipped diagnostic facilities, skilled personnel, (2) A documented history of presence of STH, (3) A known history of drug selection pressure.
- To coordinate a consensus group, consisting of WHO and (veterinary/human) parasitological laboratories (e.g. members of the Working group on STH) to develop and apply: (1) guidelines for the Faecal Egg Count Reduction Test (including statistical analyses) and to reach an agreement on the threshold for AR for a specific drug; (2) appropriate technology and methodologies for anthelminthic drug efficacy monitoring in the case of STH, and (3) control programmes in regions where anthelmintics showed a lower efficacy.
- To identify and establish guidelines for the different confounding factors which may affect anthelmintic efficacy e.g. quality of anthelmintics, intensity of infections... and to establish guidelines how to identify these factors.
- To collect suspected resistant strains of STH for further biological, molecular analysis and to distribute it to specialized research laboratories for further analysis.
- To monitor the coprological techniques used in surveys to determine efficacy of anthelmintics. As there has been relative little use of the McMaster method for human coprologic examination, constant monitoring needs to be undertaken including ring test procedures to achieve the highest level of reproducibility possible under practical conditions.
- To assist WHO in coordinating a network of scientists involved in research and development of new tools to detect and prevent anthelmintic resistance in soil transmitted helminthiasis
- Parasitic diseases other than those specifically mentioned
- Pharmaceuticals (including essential drugs and medicines)
- Health Technology (including laboratory services; but excluding blood safety)
Types of activity:
- Development and application of appropriate technology
- Providing technical advise to WHO
- Product development (guidelines; manual; methodologies; etc.)
WHO organization wide expected result:
1.5 - New knowledge, intervention tools and strategies that meet priority needs for the prevention and control of communicable diseases developed and validated, with scientists from developing countries increasingly taking the lead in this research.
+41 22 79 13322
EJOV Mikhail Nicolaevich
Access to annual progress reports and the current workplan (this is accessible to WHO Staff Members only):
Link to eWork