Study on infusion rate of snake antivenom therapy

• Register: SLCTR
• Last refreshed on: 27 April 2013
• Main ID: SLCTR/2007/005
• Date of registration: 18/05/2007
• Primary sponsor: IRQUE Project
• Public title: Study on infusion rate of snake antivenom therapy
• Scientific title: Study on infusion rate of snake antivenom therapy
• Date of first enrolment: 1/1/2007
• Target sample size: 206
• Recruitment status: Completed
• URL: http://www.slctr.lk/trial_details.asp?reg_id={335A0FAE-FDE8-4FC7-B43F-357B500F7EEA}
• Study type: Interventional
• Study design: Randomized controlled clinical trial

Countries of recruitment

Sri Lanka

Contacts

• Name: Dr. Ariaranee Gnanathasan
• Affiliation: Senior Lecturer

• Name: Dr. R.M.S.H. Karunatilake
• Affiliation: Consultant Physician

Key inclusion & exclusion criteria

Inclusion criteria: Patients with a possible clinical diagnosis of a snakebite
Exclusion criteria: * Under 14 years of age * Pregnant ladies * Previous administration of antivenom * Refusal of consent

Age minimum:
Age maximum:
Gender:

Health Condition(s) or Problem(s) studied

Snakebites requiring antivenom administration

Intervention(s)

Patients will be randomly allocated to two groups and one will receive antivenom dose over 20 minutes while the others will receive the same dose over 2 hours.

Primary Outcome(s)

Proportion with severe systemic allergic reactions within 4 hours of commencement of antivenom

Secondary Outcome(s)

* Proportion with elevated mast cell tryptase
* Proportion with elevated antivenom specific IgE
* Hospital length of stay
* Proportion with mild allergic reactions
* Proportion with delayed administration of -further antivenom therapy
* Proportion developing serum sickness

Secondary ID(s)

Nil known

Source(s) of Monetary Support

IRQUE project C1A2 MBBS SPQEF Grant