Effects of Resistance Training on Cardiovascular Risk Factors in Middle Aged Women

• Register: REBEC
• Last refreshed on: 29 April 2013
• Main ID: RBR-6gdyvz
• Date of registration: 12/12/2012
• Primary sponsor: Universidade Católica de Brasília - Brasília, DF, Brazil
• Public title: Effects of Resistance Training on Cardiovascular Risk Factors in Middle Aged Women
• Scientific title: Effects of Different Models of Undulating Periodization of Resistance Training on Cardiovascular Risk Parameters, Body Composition, Muscle Strength and Lifespam in Premenopausal Women with Metabolic Syndrome
• Date of first enrolment: 10/04/2012
• Target sample size: 60
• Recruitment status: recruiting
• URL: http://www.ensaiosclinicos.gov.br/rg/RBR-6gdyvz/
• Study design: A randomized controlled trial

Countries of recruitment

Brazil

Contacts

• Name: Ramires Tibana
• Affiliation: Universidade Católica de Brasília

• Name: Ramires Tibana
• Affiliation: Universidade Católica de Brasília

Key inclusion & exclusion criteria

Inclusion criteria: To be pre-menopausal aged between 18-49 years and no regular practice of exercise in the previous 12 months
Exclusion criteria: Use of drugs that could affect cardiovascular response to exercise and presence of any disease that would compromise their health during the study period.

Age minimum: 18Y
Age maximum: 49Y
Gender: F

Health Condition(s) or Problem(s) studied

Women with different genotypes of polymorphism of the Angiotensin Converting Enzyme (ACE)
C14.907.489

Intervention(s)

Clinical randomized controlled trial, double-blind, 3 arms. Women between 18 and 49 years will be voluntarily recruited from the local community. Each volunteer you be submitted to general physical exams, including: medical history, rest and exercise electrocardiogram, blood pressure measure before the beginning of the resistance training program. After completing the clinical exams for inclusion, will be selected 60 pre-menopausal sedentary women. They will be randomly divided into three groups of 20. Group 1 - will perform weekly undulating periodization of resistance training, group will perform daily undulating periodization, and control group. Initially, will be analyzed: 1)Maximal strength evaluations - after two weeks of adaptation to resistance exercises and clinical evaluation maximal strength (1RM) tests will be performed; 2) Resistance training - will be performed with weekly and daily undulating periodization models. En the daily undulating model, training intensity will be increased in each day of the week, for example, day 1 8-10RM (repetitions maximum) day 2 3-6RM and day 3 12-15RM load, while for the weekly undulating the intensity adjustment will occur weekly, week 1 of 8-10RM, week 2 of 3-6RM and week 3 of 12-15RM; 3) Anthropometry; 4)Body composition - body composition analysis of the volunteers, before and after the training period will be done by the Dual-energy X-ray absorptiometry; 5)Blood pressure - the measure of systolic (SBP) and diastolic blood pressure (DBP), in weeks 0, 12 and 24 will be done by the auscultatory method; 6) Cytokines measure - plasma cytokines and resistin, and salivary immunoglobulin A - saliva drawn will be performed to remove cells from the oral mucosa. Then, swabs tips will be separated with scissors and transferred to 1,5 ml to measure immunoglobulin A in saliva. Blood samples (3ml) will be collected from the antecubital vein with vaccumtainer tubes before, immediately after, 24h and 48h after the first resistance

Primary Outcome(s)

Improvement of the metabolic profile measured by blood cytokines, lipidogram, insulin and glucose

Secondary Outcome(s)

Decrease of the cardiovascular risk factors, also measured by blood pressure parameters after six months

Secondary ID(s)

279/2010

Source(s) of Monetary Support

Universidade Católica de Brasília - Brasília, DF, Brazil

Secondary Sponsor(s)

Universidade Católica de Brasília - Brasília, DF, Brazil