Glutamine metabolism in surgical patients.

• Register: Netherlands Trial Register
• Last refreshed on: 28 April 2013
• Main ID: NTR2914
• Date of registration: 24/05/2011
• Primary sponsor: VU University Medical Center
• Public title: Glutamine metabolism in surgical patients.
• Scientific title: The metabolic pathway of glutamine citrulline and arginine in surgical patients. - DIPEP HUMAN SURG
• Date of first enrolment: 1/3/2011
• Target sample size: 15
• Recruitment status: recruiting
• URL: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2914
• Study type: intervention
• Study design: Randomised: Yes; Masking: Single; Control: Active; Group: Parallel; Type: 2 or more arms, randomized

Countries of recruitment

The Netherlands

Contacts

• Name: P.A.M. Leeuwen, van

• Name: M.A.R. Vermeulen

Key inclusion & exclusion criteria

Inclusion criteria: 1. Patients undergoing aortic replacement surgery for abdominal aneurysm;

2. Age: > 35 and < 70 years;

3. BMI < 35;

4. Having obtained his/her informed consent.
Exclusion criteria: 1. Patients not fit for surgery as decided by the anesthesiology department (renal/hepatic insufficiency or heart failure);

2. Hepatitis, severe cirrhosis, urea cycle disorders/citrullinemia;

3. Kidney failure;

4. Pregnancy;

5. Corticosteroids intake in the last 4 weeks;

6. Insulin dependent diabetes mellitus;

7. Celiac disease, Crohn?s disease or other major intestinal malabsorption disorder.

Age minimum:
Age maximum:
Gender:

Health Condition(s) or Problem(s) studied

Enteral nutrition, Metabolic route, Glutamine, Citrulline, Arginine, alanyl-glutamine, Abdominal Aortic Aneurysm, Ischemia reperfusion injury, Kidney, Aortic surgery

Intervention(s)

Group A and B: 5 patients will receive a primed continuous infusion of 0.5 g/kg/24hr L-alanyl-L-glutamine intravenously, starting 12 hours before surgery.

Group C (control group): Patients do not receive L-alanyl-L-glutamine.



Each group will receive stable isotopes of glutamine, citrulline, arginine, phenylalanine and tyrosine intravenously.

Group A will receive the tracers during surgery, but before aortic clamping. Group B and C wil receive the tracers after surgery.

A renal venous blood sample will be taken during surgery but before aortic clamping.

Primary Outcome(s)

The whole body rate of appearance of glutamine, citrulline and arginine, as well as the conversion of intravenously supplied glutamine into citrulline and arginine at the whole body level.

Furtermore, renal turnover of citrulline into arginine in patients receiving L-alanyl-L-glutamine.

Secondary Outcome(s)

The quantitative effect of aortic surgery on arginine metabolism in patients treated with or without L-alanyl-L-glutamine.

Secondary ID(s)

2002-150

Source(s) of Monetary Support

VU University Medical Center