Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT01462279
• Date of registration: 25/10/2011
• Primary sponsor: Beth Israel Deaconess Medical Center
• Public title: Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness VO2
• Scientific title: The Effect of Thiamine on VO2 Levels in Critically Ill Patients
• Date of first enrolment: September 2011
• Target sample size: 20
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT01462279
• Study type: Interventional
• Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Countries of recruitment

United States

Contacts

• Name: Katherine M Berg, MD
• Affiliation: Beth Israel Deaconess Medical Center

• Name: Michael W Donnino, MD
• Affiliation: Beth Israel Deaconess Medical Center

Key inclusion & exclusion criteria

Inclusion Criteria:

- Adult patients (age > 18 years) admitted to an ICU

- Mechanically ventilated

Exclusion Criteria:

- Unstable ventilator settings during measurement of VO2

- Temp > 100 at time of VO2 measurement

- FIO2 > 60%

- Endotracheal cuff leak, chest tube, or other evident source of air leak

- Thiamine supplementation within 24 hours prior to study enrollment



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Acute Respiratory Failure

Intervention(s)

Drug: Thiamine

Primary Outcome(s)

Improvement in VO2 [Time Frame: Baseline to 9 Hours]

Secondary Outcome(s)

Improvement in hemodynamics [Time Frame: Baseline to Nine Hours]

Secondary ID(s)

2010P-000312

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

American Medical Association