The Effect of Oxytocin (OT) and Oxytocin Plus Human Chorionic Gonadotropin (hCG), in Cycles Induced by Letrozole or Clomiphene Citrate

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT00844350
• Date of registration: 13/02/2009
• Prospective Registration: No
• Primary sponsor: Tabriz University
• Public title: The Effect of Oxytocin (OT) and Oxytocin Plus Human Chorionic Gonadotropin (hCG), in Cycles Induced by Letrozole or Clomiphene Citrate
• Date of first enrolment: October 2006
• Target sample size: 177
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00844350
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
• Phase: Phase 2

Key inclusion & exclusion criteria

Inclusion Criteria:

- infertile women who had chronic anovulation

- classical PCOS with CC+hCG failure

- age <40 y

- had patent tubes on hysterosalpingography

- no other pelvic pathology

- participated in this study

Exclusion Criteria:

- hypersensitivity to any oxytocic medications

- history of cardiovascular disease

- took anti-hypertensive medications were excluded.

- women with blood pressure less than 90/60 mmHg

- abnormal spermogram

- anxiety

- excess prolactin levels

- other causes of infertility were excluded



Age minimum: 17 Years
Age maximum: 40 Years
Gender: Female

Health Condition(s) or Problem(s) studied

Ovarian Response

Intervention(s)

Drug: letrozole , oxytocin,hCG,clomiphene citrate

Primary Outcome(s)

number of follicles, endometrial thickness, and clinical pregnancy rate [Time Frame: first ,second and third month]

Secondary ID(s)

8725

Source(s) of Monetary Support

Please refer to primary and secondary sponsors