Effect of Dexamethasone on Migraine Headache

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00733382
• Date of registration: 11/08/2008
• Primary sponsor: Shiraz University of Medical Sciences
• Public title: Effect of Dexamethasone on Migraine Headache
• Scientific title: The Effect of Dexamethasone in the Attack of Migraine Headache and to Prevent of Its Relapse After Discharge From Emergency Department: a Randomized, Double-Blind, Controlled Trial.
• Date of first enrolment: February 2008
• Target sample size: 30
• Recruitment status: Active, not recruiting
• URL: http://clinicaltrials.gov/show/NCT00733382
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Countries of recruitment

Iran, Islamic Republic of

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Migraine attack according to international headache society criteria

2. Migraine without aura; at least 5 attack with mean duration of 4 to 72 hours and 2 of
following:

- Unilateral

- Pulsatile

- Severe enough to impair daily activity

- Aggravate with walking and climbing, also 1 of following:

- Nausea and or vomiting

- Photophobia and phonophobia, and not contributed to other headache.

3. Migraine with aura; at least 2 attacks with 3 of following:

- One reversible aura

- Aura became apparent at least in 4 minutes

- Aura not lasting more than 60 minutes

- Headache develops in less than 60 minutes after aura

Exclusion Criteria:

1. Hypertension

2. Ischemic heart disease

3. Basilar migraine with sign and symptoms such as:

- Diplopia

- Ataxia

- Dysarthria

- Dysphagia

- Weakness

- Sensory disorder

- Drowsiness

4. Peripheral vascular disease

5. Sepsis

6. Age more than 40 and less than 15 year old

7. Pregnancy

8. Use of triptans and ergots derivatives in past 24 hours



Age minimum: 15 Years
Age maximum: 40 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Migraine Headache

Intervention(s)

Drug: dexamethazone

Primary Outcome(s)

to evaluate the efficacy of dexamethazone in abortive therapy of migraine attack and prevent of recurrence [Time Frame: Yes]

Secondary ID(s)

212110

Source(s) of Monetary Support

Please refer to primary and secondary sponsors