Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00676585
• Date of registration: 09/05/2008
• Primary sponsor: Beth Israel Deaconess Medical Center
• Public title: Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
• Scientific title: Corticosteroids Therapy in Refractory Shock Following Cardiac Arrest
• Date of first enrolment: October 2007
• Target sample size: 50
• Recruitment status: Recruiting
• URL: http://clinicaltrials.gov/show/NCT00676585
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Countries of recruitment

United States

Contacts

• Name: Michael W Donnino, MD

• Name: Michael W Donnino, MD

• Name: Michael W Donnino, MD
• Affiliation: Beth Israel Deaconess Medical Center

Key inclusion & exclusion criteria

Inclusion Criteria:

- Greater than 18 years old

- Either pre-hospital cardiac arrest and ROSC or Inpatient Cardiac Arrest with
resultant ROSC

- Vasopressor dependent for a minimum of 1 hour post-arrest

Exclusion Criteria:

- Pregnant

- Indication for Corticosteroids outside of current research proposal

- DNR or comfort care measures

- Presence of septic shock

- Chronic Use (>1week) of oral Corticosteroids in the last year



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Cardiac Arrest

Intervention(s)

Drug: Hydrocortisone

Drug: Normal Saline

Primary Outcome(s)

Time to Shock Reversal [Time Frame: 7 Days]

Secondary Outcome(s)

Mortality [Time Frame: In Hospital]

Secondary ID(s)

2007P-000227

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

American Heart Association