Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00646126
• Date of registration: 25/03/2008
• Primary sponsor: Tropical Medicine Research Institute
• Public title: Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission
• Scientific title: Validation of the Use of Istope-Based Molecular Techniques for Malaria Control
• Date of first enrolment: August 2005
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00646126
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Countries of recruitment

Sudan

Contacts

• Name: Badria B El Sayed, PhD,MSc,BSc
• Affiliation: Tropical Medicine Research Institute

Key inclusion & exclusion criteria

Inclusion Criteria:

- All residents of the 8 villages

Exclusion Criteria:

- Pregnancy

- History of allergy to sulfa drugs



Age minimum: 1 Year
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Asymptomatic Parataemia

Plasmodium Falciparum

Sub Patent Parasitaemia

Intervention(s)

Drug: placebo tablet similar to active drug in shape and size

Drug: Sulfadoxine / Pyrimethamine (SP) plus artesunate (AS)

Primary Outcome(s)

Parsitaemia detected during the transmission season among dry season PCR negative persons in the intervention and control villages [Time Frame: October to December 2006]

Secondary Outcome(s)

1. Malaria prevalence during the transmission season 2. Frequency of mutation in drug resistance genes

Secondary ID(s)

SUD 6/025

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

International Atomic Energy Agency

London School of Hygiene and Tropical Medicine