Identification of New Colorectal Cancer Genes

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00582335
• Date of registration: 21/12/2007
• Primary sponsor: Memorial Sloan-Kettering Cancer Center
• Public title: Identification of New Colorectal Cancer Genes
• Scientific title: Identification of New Colorectal Cancer Genes
• Date of first enrolment: February 1998
• Target sample size: 337
• Recruitment status: Active, not recruiting
• URL: http://clinicaltrials.gov/show/NCT00582335
• Study type: Observational
• Study design: Observational Model: Family-Based, Time Perspective: Prospective

Countries of recruitment

United States

Contacts

• Name: Kenneth Offit, MD
• Affiliation: Memorial Sloan-Kettering Cancer Center

Key inclusion & exclusion criteria

Inclusion Criteria:

- Age 18 years or greater

- Able to provide informed consent

- Any family in which a minimum of two first-degree relatives either are, or have
previously been, affected with primary colorectalcancer. These "minimum inclusion
criteria" must be met within three generations of the proband or kindreds in which
colorectal cancer and lymphoma or renal cell cancer are present or in kindreds in
which lymphoma alone or lymphoma and renal cell cancer are present

Exclusion Criteria:

- Age less than 18 years

- Family not at increased risk for familial colorectal cancer (see Section 4.1)

- Family with a hereditary polyposis syndrome (e.g. classic FAP)

- Not able to provide informed consent



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Colorectal Cancer

Primary Outcome(s)

Evidence of mutations in selected candidate genes [Time Frame: 10 years 10 months]

Secondary ID(s)

98-003

Source(s) of Monetary Support

Please refer to primary and secondary sponsors