Does the Threat of an Aversive Reaction Affect Craving of Alcohol During Cue Exposure in Alcohol Dependent Patients?

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00372749
• Date of registration: 05/09/2006
• Primary sponsor: Assistance Publique - Hôpitaux de Paris
• Public title: Does the Threat of an Aversive Reaction Affect Craving of Alcohol During Cue Exposure in Alcohol Dependent Patients?
• Scientific title: Does the Threat of an Aversive Reaction Affect Craving of Alcohol During Cue Exposure in Alcohol Dependent Patients?
• Date of first enrolment: October 2006
• Target sample size: 30
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00372749
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Countries of recruitment

France

Contacts

• Name: Henri Jean AUBIN, MD,
• Affiliation: Assistance Publique - Hôpitaux de Paris

Key inclusion & exclusion criteria

Inclusion Criteria:

- Inpatients

- Alcohol dependence

- Detoxified since at least one week

- Willing to abstain from alcohol for at least 6 months

- Never treated with disulfiram

Exclusion Criteria:

- Any contra-indication to disulfiram

- Treated with and antidepressant or a neuroleptic medication within the 30 previous
days

- Treated with acamprosate, naltrexone, betablockers or clonidine within the 7
previous days

- Treated with benzodiazepines within the 3 previous days (except diazepam, maximum 30
mg/d)

- Anosmia



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Alcoholic Intoxication, Chronic

Intervention(s)

Behavioral: Aversive reaction during alcohol cue exposure

Primary Outcome(s)

Alcohol craving visual analogic evaluation [Time Frame: during de study]

Secondary Outcome(s)

Blood Pressure and Pulse Rate [Time Frame: during the study]

Secondary ID(s)

P051058

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Institut de Recherches Scientifiques sur les Boissons