Plasma Holotranscobalamin as Compared to Plasma Cobalamins for Assessment of Vitamin B12 Absorption

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00306358
• Date of registration: 22/03/2006
• Primary sponsor: University of Aarhus
• Public title: Plasma Holotranscobalamin as Compared to Plasma Cobalamins for Assessment of Vitamin B12 Absorption
• Scientific title: Plasma Holotranscobalamin as Compared to Plasma Cobalamins for Assessment of Vitamin B12 Absorption. Optimisation of a Non-Radioactive Vitamin B12 Absorption Test (CobaSorb)
• Date of first enrolment: May 2005
• Target sample size: 78
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00306358
• Study type: Interventional
• Study design: Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Countries of recruitment

Denmark

Contacts

• Name: Anne-Mette Hvas, Cand Med PhD
• Affiliation: Dept. of Clinical Biochemistry, Skejby Sygehus, 8000 Aarhus, Denmark

Key inclusion & exclusion criteria

Inclusion Criteria:

Above 18 years North european origin Read and understand Danish

Exclusion Criteria:

Vitamin B12 treatment within the past 5 years Use of vitamin pills containing >1 microgram
vitamin B12 with in the past 3 weeks Infectious disease Pregnancy Lactation Giving birth
within the past 9 months Use of hormones Known systemic disease



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Vitamin B12 Absorption

Intervention(s)

Drug: Vitamin B12 (Cyanocobalamin)

Primary Outcome(s)

Changes in plasma holotranscobalamin after intake of vitamin B12

Secondary Outcome(s)

Changes in plasma cobalamins, plasma methylmalonic acid and plasma homocysteine after intake of vitamin B12.

Secondary ID(s)

20050067

Source(s) of Monetary Support

Please refer to primary and secondary sponsors