Use of Beta Blockers in Elderly Trauma Patients

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00302692
• Date of registration: 10/03/2006
• Primary sponsor: University of Texas Southwestern Medical Center
• Public title: Use of Beta Blockers in Elderly Trauma Patients
• Scientific title: "Effects of Beta-Blockade on Cardiovascular Morbidity and Mortality in Elderly Trauma Patients: A Prospective Randomized Clinical Trial"
• Date of first enrolment: December 2005
• Target sample size: 148
• Recruitment status: Recruiting
• URL: http://clinicaltrials.gov/show/NCT00302692
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Countries of recruitment

United States

Contacts

• Name: Dara McBride, RN

• Name: Randall Friese, MD
• Affiliation: University of Texas Southwestern Medical Center

Key inclusion & exclusion criteria

Inclusion Criteria:

- All trauma patients admitted to the ICU > 55 years of age with a primary diagnosis of
injury will be screened on admission as study candidates.

Exclusion Criteria:

- Patients will be excluded if they have non-survivable injuries, are receiving comfort
care only, have an advanced directive limiting aggressive care, heart block, severe
asthma, bradycardia (< 60 bpm), are on beta-blocker therapy, or are having an acute
or evolving myocardial infarction.



Age minimum: 55 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Aged

Cardiovascular Diseases

Multiple Trauma

Intervention(s)

Drug: Esmolol

Drug: Metoprolol

Primary Outcome(s)

Cardiovascular Morbidity

Mortality

Secondary Outcome(s)

Inflammatory Profile

Secondary ID(s)

AHA 0465044Y

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

American Heart Association