Cognitive Remediation for Schizophrenia

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00295048
• Date of registration: 19/02/2006
• Primary sponsor: University of Maryland
• Public title: Cognitive Remediation for Schizophrenia
• Scientific title: Cognitive Remediation for Schizophrenia
• Date of first enrolment: November 2004
• Target sample size: 50
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00295048
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment

Countries of recruitment

United States

Contacts

• Name: Dwight Dickinson, PhD
• Affiliation: University of Maryland

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Diagnosis of either schizophrenia or schizoaffective disorder according to DSM-IV
criteria

2. Age 18 through 50

3. Subjects will be clinically stable as judged by current outpatient or inpatient
treatment staff

4. Primary psychiatric medication is a new generation antipsychotic other than Clozapine
and/or a dose of first generation antipsychotic equivalent to 10 mg. of less of
haloperidol for one month prior to enrollment.

Exclusion Criteria:

1. Documented history of organic brain disease

2. Documented history of mental retardation

3. Physical limitations (e.g., with hearing or vision) that would interfere
substantially with use of computer-based exercises

4. Diagnosis of current Substance Dependence according to DSM-IV criteria

5. Participation in the prior full trial of this remediation program (this exclusion is
meant to apply to individuals participating in the full controlled trial, and not to
individuals participating in the preliminary sub-study).



Age minimum: 18 Years
Age maximum: 50 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Schizophrenia

Intervention(s)

Behavioral: Computer Assisted Cognitive Remediation (CACR)

Primary Outcome(s)

broad cognitive performance (as indexed by a composite of the neuropsychological measures) and on a composite of everyday problem solving

Secondary Outcome(s)

individual cognitive domains and individual everyday problem solving domains, the interaction of treatment with various other variables

Secondary ID(s)

24292

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

National Institute of Mental Health (NIMH)

VISN 5 Mental Illness Research, Education and Clinical Center