Study of the Role of Dendritic Cells in the Recurrence of Hepatitis C After Liver Transplantation. Analysis of Hepatitis C Virus (HCV) Quasispecies Evolution.

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00213707
• Date of registration: 13/09/2005
• Primary sponsor: University Hospital, Strasbourg, France
• Public title: Study of the Role of Dendritic Cells in the Recurrence of Hepatitis C After Liver Transplantation. Analysis of Hepatitis C Virus (HCV) Quasispecies Evolution.
• Scientific title: Liver Transplanted Patients for HCV Related End Stage Liver Disease.Functional Role of Blood Circulating Dendritic Cells in the Pathogenesis of Hepatitis C Virus Infection During Liver Transplantation.
• Date of first enrolment: May 2003
• Target sample size: 30
• Recruitment status: Active, not recruiting
• URL: http://clinicaltrials.gov/show/NCT00213707
• Study type: Observational
• Study design: Observational Model: Cohort, Time Perspective: Prospective

Countries of recruitment

France

Contacts

• Name: Francoise Stoll-Keller, MD
• Affiliation: Hopitaux Universitaires de Strasbourg

Key inclusion & exclusion criteria

Inclusion Criteria:

Liver transplanted HCV infected patients :

- Adults, HIV(-),HBV(-)

- liver transplanted for an end stage liver disease associated to HCV.

- Genotype determined

- written agreement to participate to the study

Control patients :

- Adults, HIV(-), HBV(-), HCV(-)

- liver transplanted for a non HCV liver disease

- written agreement to participate to the study.

Exclusion Criteria:

- HIV(+), HBV(+)



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

HCV Infection

Primary Outcome(s)

Function of blood circulating DC at day 7 and 1, 3, 6, 9, 12 months, 2 and 5 years after liver transplantation depending on the clinical outcome (mild or severe hepatitis, cirrhosis). [Time Frame: 5 years]

Secondary ID(s)

2864

Source(s) of Monetary Support

Please refer to primary and secondary sponsors