Implementation of a New Strategy to Identify HNPCC Patients

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00141466
• Date of registration: 31/08/2005
• Primary sponsor: Radboud University
• Public title: Implementation of a New Strategy to Identify HNPCC Patients
• Scientific title: Cost Effectiveness of Two Different Implementation Procedures to Change Clinicians Practice Roles in the Detection of Hereditary Colorectal Cancer
• Date of first enrolment: September 2005
• Target sample size: 360
• Recruitment status: Recruiting
• URL: http://clinicaltrials.gov/show/NCT00141466
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind

Countries of recruitment

Netherlands

Contacts

• Name: Lucy I Overbeek, MSc

• Name: Rosella P Hermens, MSc PhD
• Affiliation: Center of Quality of Care Research, Radboud University Nijmegen Medical Center

• Name: Nicoline Hoogerbrugge, MD PhD
• Affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Center

Key inclusion & exclusion criteria

Inclusion Criteria:

- Colorectal cancer before the age of 50 years

- Second colorectal cancer at any age

- Colorectal cancer and other HNPCC associated extracolonic cancer irrespective of age
at diagnosis

- Adenoma with high grade dysplasia diagnosed before the age of 40 years



Age minimum: N/A
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Colorectal Neoplasms

Hereditary Nonpolyposis Colorectal Cancer

Intervention(s)

Behavioral: Distribution of educational materials

Behavioral: Education for professionals

Behavioral: Feedback for professionals

Behavioral: Reminders for professionals

Primary Outcome(s)

Efficacy of inclusion of eligible CRC-patients for MSI testing by pathologists.

Efficacy of referral of patients who are MSI positive to a clinical geneticist by surgeons.

Secondary Outcome(s)

Cost efficacy of the implementation procedures.

Experiences with and acceptance of changed physician practice roles by patients and clinicians.

Secondary ID(s)

MIPA-2005

ZonMw nr. 945-14-107

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

ZonMw: The Netherlands Organisation for Health Research and Development