Green Tea and Ultraviolet Light-induced Skin Damage

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00134381
• Date of registration: 22/08/2005
• Primary sponsor: University of Medicine and Dentistry New Jersey
• Public title: Green Tea and Ultraviolet Light-induced Skin Damage
• Scientific title: The Effects of Topically Applied Constituents of Green Tea on UV Induced Increase in p53 and Apoptotic Markers in the Skin of Human Volunteers
• Date of first enrolment: May 2003
• Target sample size: 168
• Recruitment status: Active, not recruiting
• URL: http://clinicaltrials.gov/show/NCT00134381
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Countries of recruitment

United States

Contacts

• Name: Melissa Magliocco, MD
• Affiliation: University of Medicine and Dentistry New Jersey

Key inclusion & exclusion criteria

Inclusion Criteria:

- The subjects will be normal adult volunteers who are 18 to 65 years of age.

Exclusion Criteria:

- Subjects who drink more than two cups of coffee, tea, or caffeinated soda/beverages
per day.

- Subjects who are unable to get an erythemic response (i.e., a sunburn).



Age minimum: 18 Years
Age maximum: 65 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Healthy

Intervention(s)

Drug: Green Tea

Primary Outcome(s)

Enhancement of UV-induced p53 and markers of apoptosis by green tea compounds [Time Frame: 48 hrs]

Secondary Outcome(s)

Reduction of UV-induced erythema by green tea compounds [Time Frame: 48 hrs]

Secondary ID(s)

3808

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Rutgers University