Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00131833
• Date of registration: 18/08/2005
• Primary sponsor: International Vaccine Institute
• Public title: Typhoid Vi Vaccine Effectiveness in Hechi, Guangxi, China
• Scientific title: Typhoid Vi Vaccine Effectiveness in a Population Older Than 5 Years of Age Living in an Endemic Area in Hechi, Guangxi, P.R. China: A Group-Randomized Controlled Demonstration Project
• Date of first enrolment: October 2001
• Target sample size: 96468
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00131833
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Prevention

Countries of recruitment

China

Contacts

• Name: Dong Baiqing, MD
• Affiliation: Guangxi Center for Disease Control and Prevention

Key inclusion & exclusion criteria

Inclusion Criteria:

- Registered in the project census

Exclusion Criteria:

- Pregnant

- Lactating

- Fever > 37.5 degrees Celsius, axillary



Age minimum: 5 Years
Age maximum: 60 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Paratyphoid Fever

Typhoid

Intervention(s)

Biological: Meningococcal A (control)

Biological: Typhoid Vi vaccine

Primary Outcome(s)

adverse events

cost effectiveness of typhoid Vi immunization

vaccine effectiveness

Secondary Outcome(s)

anti-Vi antibody response

knowledge, attitudes, beliefs and practices of parents and health care providers on typhoid fever prevention and treatment

logistic feasibility of mass typhoid immunization

Typhoid risk factors

Secondary ID(s)

T3

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Centers for Disease Control and Prevention

Hechi City Center for Disease Centrol

University of Western Ontario, Canada

Wellcome Trust