The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome

• Register: ClinicalTrials.gov
• Last refreshed on: 17 October 2012
• Main ID: NCT00001343
• Date of registration: 03/11/1999
• Primary sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Public title: The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
• Scientific title: The Relative Effects of Androgen, Estrogen, and the Combination of Androgen and Estrogen on Growth Rate, GH Binding Protein, IGF-I, and Cognitive Function in Growth Hormone-Treated Girls With Turner Syndrome
• Date of first enrolment: December 1992
• Target sample size: 80
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00001343
• Study type: Interventional
• Study design: Primary Purpose: Treatment

Countries of recruitment

United States

Key inclusion & exclusion criteria

- INCLUSION CRITERIA:

Girls with Turner syndrome will qualify to participate in this study if they meet the
following criteria:

Karyotype diagnosis compatible with Turner syndrome.

No treatment with estrogen, androgen or growth hormone exceeding twelve months, and no
treatment with either of these agents in the preceding 3 months.

Chronological age of 10.0 to 14.9 years.

Bone age less than or equal to 12 years.

EXCLUSION CRITERIA:

Prior treatment with estrogen, androgen, or growth hormone for more than twelve months.

Y component in peripheral karyotype.



Age minimum: 10 Years
Age maximum: 14 Years
Gender: Female

Health Condition(s) or Problem(s) studied

Dwarfism

Turner's Syndrome

Intervention(s)

Drug: Humatrope

Drug: Oxandrolone

Secondary ID(s)

93-CH-0054

930054

Source(s) of Monetary Support

Please refer to primary and secondary sponsors