Host Response to Infection and Treatment in Filarial Diseases

• Register: ClinicalTrials.gov
• Last refreshed on: 7 January 2013
• Main ID: NCT00001230
• Date of registration: 03/11/1999
• Primary sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
• Public title: Host Response to Infection and Treatment in Filarial Diseases
• Scientific title: Host Response to Infection and Treatment in the Filarial Diseases of Humans
• Date of first enrolment: May 1988
• Target sample size: 500
• Recruitment status: Recruiting
• URL: http://clinicaltrials.gov/show/NCT00001230
• Study type: Observational
• Study design: N/A

Countries of recruitment

United States

Contacts

• Name: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)

• Name: Thomas B Nutman, M.D.

• Name: Thomas B Nutman, M.D.
• Affiliation: National Institute of Allergy and Infectious Diseases (NIAID)

Key inclusion & exclusion criteria

- INCLUSION CRITERIA:

Age 1-100 years.

Access to a primary medical care provider outside of the NIH.

Ability to give informed consent.

Clinical evidence suggestive of a filarial infection

Therapeutic plasmapheresis or leukapheresis:

- individuals 18 years of age or older

- greater than 55 kgs with the objective of decreasing their filarial burden prior to
treatment.

Research plasmapheresis or leukapheresis

- 18 years of age or older

- greater than 55 kgs.

EXCLUSION CRITERIA:

Pregnant or nursing women will be excluded from the treatment arm of the study.

Less than 1 year of age; greater than 100 years of age.

For research pheresis:

- No clinical contraindications to the procedure

- severe anemia

- cardiovascular disease

- coagulopathy



Age minimum: 1 Year
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Filariasis

Helminthiasis

Loiasis

Mansonelliasis

Onchocerciasis

Secondary ID(s)

88-I-0083

880083

Source(s) of Monetary Support

Please refer to primary and secondary sponsors