Optimisation of vitamin A dosing schedules in infancy

• Register: ISRCTN
• Last refreshed on: 12 February 2013
• Main ID: ISRCTN98554309
• Date of registration: 10/10/2005
• Primary sponsor: Medical Research Council (UK)
• Public title: Optimisation of vitamin A dosing schedules in infancy N/A
• Date of first enrolment: Sep 1 2001
• Target sample size: 220
• Recruitment status: Completed/Not recruiting
• URL: http://isrctn.org/ISRCTN98554309
• Study type: Interventional
• Study design: Randomised controlled trial

Countries of recruitment

Gambia

Contacts

• Name: Andrew Prentice

Key inclusion & exclusion criteria

Inclusion criteria: Consenting mothers and new born infants in six villages in the West Kiang region of The Gambia.
Exclusion criteria: 1. Congenital defects
2. Birthweight under 2200 g

Age minimum:
Age maximum:
Gender:

Health Condition(s) or Problem(s) studied

Vitamin A deficiency

Intervention(s)

Early high dose Vitamin A schedule versus standard WHO schedule.

Primary Outcome(s)

1. Vitamin A status in mothers and infants
2. Heliobacter pylori infection in infants
3. Nasopharyngeal pneumococcal carriage in mothers and infants
4. Gut permeability in infants assessed by Dual Pugar Permeability Test (DSPT)

Secondary Outcome(s)

1. Infant growth
2. Infant morbidity
3. Breast milk sodium-potassium ratios
4. Breast-milk oligosaccharides

Secondary ID(s)

N/A

Source(s) of Monetary Support

Medical Research Council (UK)

Secondary Sponsor(s)

N/A