The effect of anesthetic on postoperative cognitive dysfunction and relative protein in CSF in elder

• Register: ChiCTR
• Last refreshed on: 18 April 2017
• Main ID: ChiCTR-TRC-08000187
• Date of registration: 2008-11-15
• Prospective Registration: No
• Primary sponsor: Beijing Friendship Hospital, Capital Medical University
• Public title: The effect of anesthetic on postoperative cognitive dysfunction and relative protein in CSF in elder
• Scientific title: The effect of anesthetic on postoperative cognitive dysfunction and relative protein in CSF in elder
• Date of first enrolment: 2008-01-01
• Target sample size: SI group:15;S group:15;SP group:15;SD group:15;
• Recruitment status: Completed
• URL: http://www.chictr.org.cn/showproj.aspx?proj=9338
• Study type: Interventional study
• Study design: Randomized parallel controlled trial
• Phase: I (Phase I study)

Countries of recruitment

China

Contacts

• Name: Bin Zhang
• Affiliation: Beijing Friendship Hospital, Capital Medical University

• Name: Bin Zhang

Key inclusion & exclusion criteria

Inclusion criteria: Patients aged from 65-75 years old and schedule to undergo lower limb or hypogastrium operation; ASA I-II; without mental or neurologic disease;educated; no disorder in auditus, vision and language. And all patients accept continuous spinal anesthesia.
Exclusion criteria: Patients will be excluded when
(1) They are over 75 yrs or below 65 yrs;
(2) They can't accept continuous spinal anesthesia;
(3) They have mental or neurologic disease;
(4) ASA III or higher;
(5) They have contraindication to relative drug;
(6) They have anxiety-depression or severe complication after operation;
(7)They are taking part in other trial.

Age minimum: 65
Age maximum: 75
Gender: Both

Health Condition(s) or Problem(s) studied

Alzheimer disease; Postoperative cognitive dysfunction.

Intervention(s)

SI group:After continuous spinal anesthesia is stable, we inject propofol 2mg/kg, then insert LMA and make 1-1.5MAC isoflurane inhaled 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing, collecting CSF 1-1.5ml before and 2 hours after isoflurane inhalation, respectively. ;S group:Continuous spinal anesthesia only. Collecting CSF 1-1.5ml before and 2 hours after anesthesia respectively. ;SP group:After continuous spinal anesthesia is stable, inject propofol 2mg/kg, then insert LMA and infuse propofol 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing, collecting CSF 1-1.5ml before and 2 hours after propofol infusing, respectively. ;SD group:After continuous spinal anesthesia is stable, inject propofol 2mg/kg, then insert LMA and make 1-1.5MAC desflurane inhaled 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing, collecting CSF 1-1.5ml before and 2 hours after desflurane inhalation respectively;

Primary Outcome(s)

A beta 40 and A beta 42 in CS;

Secondary Outcome(s)

IL-1beta, TNF-alpha, S100 beta, NSE in CS;

Source(s) of Monetary Support

Beijing Friendship Hospital, Capital Medical University