The effect of anesthetic on postoperative cognitive dysfunction and relative protein in CSF in elder

• Register: ChiCTR
• Last refreshed on: 28 April 2013
• Main ID: ChiCTR-TRC-08000187
• Date of registration: 2008-12-10
• Primary sponsor: Beijing Friendship Hospital, Capital Medical University
• Public title: The effect of anesthetic on postoperative cognitive dysfunction and relative protein in CSF in elder
• Scientific title: The effect of anesthetic on postoperative cognitive dysfunction and relative protein in CSF in elder
• Date of first enrolment: 2008-01-01
• Target sample size: SI group:15;S group:15;SP group:15;SD group:15;
• Recruitment status: Recruiting
• URL: http://www.chictr.org/en/proj/show.aspx?proj=1201
• Study type: Interventional
• Study design: Randomized parallel control

Countries of recruitment

China

Contacts

• Name: Bin Zhang

• Name: Bin Zhang

Key inclusion & exclusion criteria

Inclusion criteria: Patients aged from 65-75 years old and schedule to undergo lower limb or hypogastrium operation; ASA ?-?;without mental or neurologic disease;educated;no disorder in auditus,vision and language.And all patients accept continuous spinal anesthesia.
Exclusion criteria: Patients will be excluded when(1)They are over 75 yrs or below 65 yrs;(2)They can't accept continuous spinal anesthesia;(3)They have mental or neurologic disease;(4)ASA ? or higher;(5)They have contraindication to relative drug;(6)They have anxiety-depression or severe complication after operation;(7)They are taking part in other trial.

Age minimum: 65
Age maximum: 75
Gender: Both

Health Condition(s) or Problem(s) studied

Alzheimer disease; Postoperative cognitive dysfunction.

Intervention(s)

SI group:After continuous spinal anesthesia is stable, we inject propofol 2mg/kg, then insert LMA and make 1-1.5MAC isoflurane inhaled 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing, collecting CSF 1-1.5ml before and 2 hours after isoflurane inhalation, respectively.;S group:Continuous spinal anesthesia only. Collecting CSF 1-1.5ml before and 2 hours after anesthesia respectively.;SP group:After continuous spinal anesthesia is stable, inject propofol 2mg/kg, then insert LMA and infuse propofol 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing, collecting CSF 1-1.5ml before and 2 hours after propofol infusing, respectively.;SD group:After continuous spinal anesthesia is stable, inject propofol 2mg/kg, then insert LMA and make 1-1.5MAC desflurane inhaled 2 hours continuously to maintain BIS between 50-60, remaining spontaneously breathing, collecting CSF 1-1.5ml before and 2 hours after desflurane inhalation respectively.;

Primary Outcome(s)

Aß40 and Aß42 in CSF;

Secondary Outcome(s)

IL-1ß, TNF-a, S100ß, NSE in CSF;

Source(s) of Monetary Support

Beijing Friendship Hospital, Capital Medical University