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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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12 December 2020 |
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Main ID: |
NCT02753426 |
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Date of registration:
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24/04/2016 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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A Trial of Doxycycline in Renal Disease
ADORE |
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Scientific title:
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A Trial of Doxycycline in Renal Disease (ADORE) |
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Date of first enrolment:
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April 2016 |
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Target sample size:
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11 |
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Recruitment status: |
Completed |
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URL:
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https://clinicaltrials.gov/show/NCT02753426 |
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Study type:
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Interventional |
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Study design:
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Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Prevention. Masking: Double (Participant, Investigator).
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Phase:
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Phase 1
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Countries of recruitment
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United States
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Contacts
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Name:
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Ruth Dubin, MD |
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Address:
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Telephone:
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Email:
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Affiliation:
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University of California, San Francisco |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- CKD pre-dialysis (eGFR< 30 ml/min/1.73m2 not on dialysis);
- local 415/650/510 area codes;
- primary language English or Spanish
Exclusion Criteria:
- eGFR worsening by greater than 5ml/min/1.73 m2 during the last 6 months;
- Systolic blood pressure less than 100mmHg or greater than 170 mmHg;
- pregnancy;
- ejection fraction less than 45%;
- NYHA class III or IV HF;
- myocardial infarction or hospitalization for HF within 4 months;
- liver disease;
- moderate or severe chronic obstructive pulmonary disease or pulmonary fibrosis;
- current infection;
- chemotherapy;
- major surgery within last month;
- bilateral dialysis access precluding lab draw;
- self-reported use of IV drugs or cocaine within the last 6 months.
Age minimum:
18 Years
Age maximum:
N/A
Gender:
All
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Health Condition(s) or Problem(s) studied
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Chronic Kidney Disease
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Cardiorenal Syndrome
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Intervention(s)
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Drug: Placebo (for Doxycycline)
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Drug: Doxycycline
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Primary Outcome(s)
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Serum markers of fibrosis
[Time Frame: 3 months]
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Urinary markers of fibrosis
[Time Frame: 3 months]
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Secondary Outcome(s)
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Adverse effects
[Time Frame: 3 months]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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