Targeted Internal Radiation Therapy in Advanced HCC Patients.

• Register: ClinicalTrials.gov
• Last refreshed on: 11 April 2016
• Main ID: NCT02724267
• Date of registration: 28/03/2016
• Prospective Registration: No
• Primary sponsor: Eastern Hepatobiliary Surgery Hospital
• Public title: Targeted Internal Radiation Therapy in Advanced HCC Patients.
• Scientific title: A Randomized Controlled Prospective Study of Targeted Internal Radiation Therapy in Patients With Advanced Hepatocellular Carcinoma.
• Date of first enrolment: November 2012
• Target sample size: 200
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02724267
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
• Phase: N/A

Countries of recruitment

China

Key inclusion & exclusion criteria

Inclusion Criteria:

1. Via clinical diagnosis and confirm it is advanced hepatocellular carcinoma

2. mRECIST estimation: necrosis region in HCC

3. Negative iodine allergy test

4. Liver function :Child-Pugh A/B

Exclusion Criteria:

1. reject to attend;

2. impossible to come to our hospital for physical examination regularly.

3. Blood clotting function hindrance; 4, Patients with apparent cardiac, pulmonary,
cerebral and renal dysfunction,which may affect the treatment of liver cancer.



Age minimum: 18 Years
Age maximum: 70 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Advanced Hepatocellular Carcinoma

Internal Radiation

Intervention(s)

Biological: 131I-chTNT-1/B

Primary Outcome(s)

Overall Survival [Time Frame: 3 years]

Secondary Outcome(s)

Time to Progression [Time Frame: 3 years]

Secondary ID(s)

ZD201208002-P1

Source(s) of Monetary Support

Please refer to primary and secondary sponsors