Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT02134561
• Date of registration: 10/04/2014
• Prospective Registration: No
• Primary sponsor: University Hospital, Angers
• Public title: Assessment of the Psychological, Cognitive and Social Resources of Applicants for Huntington's Disease and Presymptomatic Genetic Testing PREHUNT
• Date of first enrolment: September 2013
• Target sample size: 24
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02134561
• Study type: Interventional
• Study design: Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Supportive Care. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

France

Key inclusion & exclusion criteria

Inclusion Criteria:

- Applicants for Huntington's Disease and Presymptomatic Testing

- Aged 18 years and above

- Huntington disease family member

- Subject gave its written consent

Exclusion Criteria:

- No national health insurance affiliation

- Being under guardianship

- Meeting brain MRI exclusion criteria (pacemakers, aneurysm clips, artificial heart
valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body,
Renal failure, hypersensitivity of Gadolinium) or refusing MRI.

- Patient with movement disorder



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Presymptomatic Huntington Disease

Intervention(s)

Radiation: MRI

Other: neurological tests

Other: cognitive tests

Behavioral: psychological interview

Primary Outcome(s)

Change from baseline total score of the psychological Unified Huntington's Disease Rating Scale at 2 years [Time Frame: 3 months before diagnostic (baseline) ; 2 years after diagnostic,]

Secondary ID(s)

2013-A00088-37

Source(s) of Monetary Support

Please refer to primary and secondary sponsors