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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ClinicalTrials.gov |
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Last refreshed on:
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12 December 2020 |
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Main ID: |
NCT02116270 |
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Date of registration:
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09/04/2014 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Accelerated Immunosenescence and Chronic Kidney Disease
IRIS |
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Scientific title:
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Accelerated Immunosenescence and Chronic Kidney Disease |
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Date of first enrolment:
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September 2013 |
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Target sample size:
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222 |
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Recruitment status: |
Completed |
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URL:
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https://clinicaltrials.gov/show/NCT02116270 |
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Study type:
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Interventional |
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Study design:
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Allocation: Non-Randomized. Intervention model: Parallel Assignment. Primary purpose: Other. Masking: None (Open Label).
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Phase:
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N/A
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Countries of recruitment
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France
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Contacts
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Name:
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Jamal BAMOULID, Doctor |
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Address:
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Telephone:
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Email:
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Affiliation:
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CHU de Besançon |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Patient able to understand the reason of the study
- Patient not opposed to the conservation of biological samples for scientific research
Exclusion Criteria:
- Patient suffering from psychotic illness
- Any history of immunosuppressive therapy (except steroids up to 5mg/day)
- History of cancer (except skin cancer) or treated hematological malignancy
- Infectious episode required hospitalization not older 3 months
- Hepatitis B or C infection
- HIV infection, active or inactive
- For dialysis patients: renal failure on dialysis for less than 3 months and/or have
benefited from two techniques for renal replacement therapy in the last 6 months
Age minimum:
18 Years
Age maximum:
85 Years
Gender:
All
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Health Condition(s) or Problem(s) studied
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Renal Failure
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Intervention(s)
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Biological: Blood sample
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Primary Outcome(s)
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Percentage of Cluster of Differentiation (CD) 4/8+ CD 57+ CD 28- lymphocytes (senescent lymphocytes)
[Time Frame: 6 months]
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Secondary Outcome(s)
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Proportion of Recent Thymic Emigrants (RTE) in peripheral blood T lymphocytes
[Time Frame: 6 months]
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Telomere length in T lymphocytes
[Time Frame: 6 months]
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Level of phospho-histone 2AX (gH2AX) in peripheral blood T lymphocytes
[Time Frame: 6 months]
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Telomerase Activity of T lymphocytes
[Time Frame: 6 months]
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T-cell receptor excision circle (TREC) level in PBMC.
[Time Frame: 6 months]
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Secondary ID(s)
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IRIS API/2012/28
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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