Diet Induced Intestinal Mucosal Adaptation

• Register: ClinicalTrials.gov
• Last refreshed on: 26 October 2021
• Main ID: NCT02088853
• Date of registration: 13/03/2014
• Prospective Registration: No
• Primary sponsor: Göteborg University
• Public title: Diet Induced Intestinal Mucosal Adaptation
• Scientific title: Small Intestinal Adaptation to Isocaloric Diets Dominated Either by Fats or Carbohydrates
• Date of first enrolment: March 2014
• Target sample size: 17
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02088853
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Crossover Assignment. Primary purpose: Basic Science. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

Sweden

Contacts

• Name: Lars Fändriks, MD, PhD
• Affiliation: Göteborg University

Key inclusion & exclusion criteria

Inclusion Criteria:

healthy volunteer not taking prescribed medications BMI =25 kg/m2

Exclusion Criteria:

BMI =26 kg/m2 smoker previous or current gastrointestinal disease significant abdominal
surgery pregnancy/breast feeding drug intolerance of importance (particularly opiates and
midazolam used during endoscopy) history of drug addiction



Age minimum: 18 Years
Age maximum: 65 Years
Gender: All

Health Condition(s) or Problem(s) studied

Healthy Conditions

Intervention(s)

Dietary Supplement: high carb diet

Dietary Supplement: high fat diet (hfd)

Primary Outcome(s)

Mucosal surface enlargement factor [Time Frame: Appearance after 2 weeks of diet]

Secondary Outcome(s)

Glycemic control following a test meal [Time Frame: The condition after 2 weeks diet]

Mucosal electrical resistance in vitro [Time Frame: The condition after 2 weeks diet]

Epithelial electrical current in-vitro [Time Frame: The condition after 2 weeks diet]

Secondary ID(s)

BUTTER

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Sahlgrenska University Hospital, Sweden