Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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1 March 2021 |
Main ID: |
NCT01842321 |
Date of registration:
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24/04/2013 |
Prospective Registration:
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Yes |
Primary sponsor: |
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Public title:
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Abiraterone Acetate in Molecular Apocrine Breast Cancer
AMA |
Scientific title:
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A Phase II Trial Evaluating the Activity of Abiraterone Acetate Plus Prednisone in Patients With a Molecular Apocrine HER2-negative Locally Advanced or Metastatic Breast Cancer |
Date of first enrolment:
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July 2013 |
Target sample size:
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34 |
Recruitment status: |
Completed |
URL:
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https://clinicaltrials.gov/show/NCT01842321 |
Study type:
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Interventional |
Study design:
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Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Treatment. Masking: None (Open Label).
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Phase:
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Phase 2
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Countries of recruitment
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France
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Contacts
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Name:
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Hervé BONNEFOI, Prof. |
Address:
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Telephone:
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Email:
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Affiliation:
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Institut Bergonié, Bordeaux |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Women aged =18 years;
- Histologically confirmed locally advanced or metastatic breast cancer;
- Triple negative breast cancer:
Estrogen receptor (ER)-negative and Progesterone receptor (PR)-negative, as defined by a
<10 % tumour stained cells by immunohistochemistry (IHC); HER2 negative status (i.e. IHC
score 0 or 1+, or IHC score 2+ and FISH/SISH/CISH negative), confirmed centrally before
inclusion with FFPE tissue from either primary or metastatic breast cancer site*;
- Androgen receptor (AR)-positive, as defined centrally by a =10% tumour stained cells
by IHC (AR assessment by local pathologist before inclusion is not mandatory);
- Patients could be chemotherapy naïve (provided they are not presenting with
life-threatening metastasis) or have received any number of previous lines of
chemotherapy (providing their life expectancy is =3 months);
- Pre and post menopausal patients are eligible.
- Measurable or non measurable disease according to RECIST v1.1 criteria;
- PS (ECOG) =2;
- Normal haematological function: ANC =1,500/mm3; platelets count =100,000/mm3;
haemoglobin >10 g/dl;
- Normal hepatic function: total bilirubin =1.5 upper normal limit (UNL); ASAT and ALAT
=2.5 UNL (=5 UNL in the presence of liver metastases);
- Creatinine clearance (MDRD formula) =50 mL/min OR creatinine =1.5 times ULN;
- Normal kalemia (serum potassium =3.5 mM), natremia and magnesemia;
- Systolic blood pressure (BP) <160 mm Hg and diastolic BP <95 mm Hg, as documented on
inclusion day (Hypertension at baseline assessment allowed provided it is currently
controlled under anti-hypertensive drugs);
- Cardiac ejection fraction =50% measured by MUGA or ECHO done within 4 weeks before
inclusion;
- If receiving a bisphosphonate or denosumab, dose must have been stable for at least 2
doses before inclusion;
- Patient agreeing to use effective contraception during and for = 6 months after
completion of study treatment;
- Patient able to comply with the protocol;
- Patient must have signed a written informed consent form prior to any study specific
procedures;
- Patient must be affiliated to a Social Health Insurance.
Exclusion Criteria:
- Male breast cancer;
- HER2-positive status (positivity defined as IHC3+ and/or FISH amplification >2.2);
- Other concurrent malignancies, except adequately treated cone-biopsied in situ
carcinoma of the cervix or basal cell or squamous cell carcinoma of the skin; patients
who have undergone potentially curative therapy for a prior malignancy are eligible
provided there is no evidence of disease for = 5 years and patient is deemed to be at
low risk for recurrence;
- Active brain metastases or leptomeningeal disease; History of brain metastases allowed
provided lesions are stable for at least 3 months as documented by head CT scan or MRI
of the brain;
- Non-malignant systemic disease, including active infection or concurrent serious
illness that would make the patient a high medical risk;
- Significant cardiovascular disease, including any of the following:
1. NYHA class III-IV congestive heart failure;
2. Unstable angina pectoris or myocardial infarction within the past 6 months;
3. Severe valvular heart disease;
4. Ventricular arrhythmia requiring treatment.
- Patients with rare hereditary problems of galactose intolerance, the Lapp lactase
deficiency or glucose-galactose malabsorption should not be included;
- Patients with known allergies, hypersensitivity or intolerance to abiraterone acetate,
prednisone, or their excipients;
- Persistent toxicities = grade 2 from any cause, except chemotherapy-induced alopecia
and Grade 2 peripheral neuropathy;
- Active or uncontrolled autoimmune disease requiring concurrent corticosteroid therapy;
- Any gastrointestinal disorder interfering with absorption of the study drug;
- Difficulties with swallowing study capsules;
- Prior anticancer therapy, including radiotherapy, endocrine therapy, immunotherapy,
chemotherapy (CT) within the last 3 weeks (2 weeks for oral or weekly CT ; 6 weeks for
nitrosoureas and mitomycin C), or other investigational agents ; Concurrent palliative
radiotherapy allowed;
- Concurrent enrolment in another clinical trial in which investigational therapies are
administered;
- Pregnant women, women who are likely to become pregnant or are breast-feeding;
- Patients with any psychological, familial, sociological or geographical condition
potentially hampering compliance with the study protocol and follow-up schedule; those
conditions should be discussed with the patient before registration in the trial;
- Patients with history of non compliance to medical regimens or unwilling or unable to
comply with the protocol;
- Individual deprived of liberty or placed under the authority of a tutor.
Age minimum:
18 Years
Age maximum:
N/A
Gender:
Female
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Health Condition(s) or Problem(s) studied
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Breast Cancer
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Intervention(s)
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Drug: Abiraterone Acetate
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Primary Outcome(s)
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Clinical benefit rate (CBR)
[Time Frame: at 6 months]
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Secondary Outcome(s)
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Duration of overall response (DoR)
[Time Frame: at 6 months]
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Overall safety profile
[Time Frame: during the on-treatment period (defined as the period from the time of first dose of study medications up to 30 days of the last dose)]
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Objective response rate (ORR)
[Time Frame: at 6 months]
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Progression-free survival (PFS)
[Time Frame: median follow-up = 2 years]
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Overall Survival (OS)
[Time Frame: median follow-up = 2 years]
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Secondary ID(s)
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2012-002525-29
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CADUSEIME02
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UC-0140/1206
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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