Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT01489072
• Date of registration: 05/12/2011
• Prospective Registration: Yes
• Primary sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
• Public title: Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia
• Scientific title: Comparison of the Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia.
• Date of first enrolment: April 2012
• Target sample size: 180
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT01489072
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
• Phase: N/A

Countries of recruitment

Canada

Contacts

• Name: Nathalie Massicotte, MD, FRCPC
• Affiliation: Centre Hospitalier de l'Université de Montréal

Key inclusion & exclusion criteria

Inclusion Criteria:

- Patients aged 18-80 years

- Physical status 1-3

- Patients undergoing elective surgery under general anesthesia requiring endotracheal
intubation (excluding head and neck surgery)

Exclusion Criteria:

- Current use of ACE inhibitors

- Chronic cough

- Asthma or severe pulmonary disease

- Pulmonary tract infection

- Anticipated difficult intubation

- Current use of opioids

- Current use of cough medicine

- Contraindication to remifentanil

- Pregnancy

- Symptomatic cardiac, renal or hepatic disease



Age minimum: 18 Years
Age maximum: 80 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Cough

Anesthesia

Intervention(s)

Drug: Remifentanil

Primary Outcome(s)

Incidence of coughing during emergence and the first ten minutes after extubation [Time Frame: From emergence until 10 minutes after extubation]

Secondary Outcome(s)

Incidence of sore throat one hour after extubation [Time Frame: Assessed one hour after extubation]

Time elapsed between the bolus dose of remifentanil and extubation [Time Frame: Assessed at emergence of general anesthesia]

Secondary ID(s)

NM 2012-002

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Centre de Recherche du Centre Hospitalier de l'Université de Montréal