Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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14 March 2016 |
Main ID: |
NCT01488838 |
Date of registration:
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07/12/2011 |
Prospective Registration:
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No |
Primary sponsor: |
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Public title:
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A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
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Scientific title:
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Date of first enrolment:
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November 2011 |
Target sample size:
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120 |
Recruitment status: |
Completed |
URL:
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https://clinicaltrials.gov/show/NCT01488838 |
Study type:
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Interventional |
Study design:
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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Phase:
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Phase 2
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Countries of recruitment
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Saudi Arabia
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Key inclusion & exclusion criteria
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Inclusion Criteria:
1. Pathologically proven diagnosis of a malignant major salivary gland tumor of the
following histologic subtypes: high grade mucoepidermoid carcinoma, salivary duct
carcinoma or high grade adenocarcinoma;
2. Surgical resection with curative intent within 8 weeks prior to registration;
3. Pathologic stage T3-4 or N1-3 or T1-2, N0 with a close (=1mm) or microscopically
positive surgical margin (AJCC, 7th ed.; see Appendix IV); patients must be free of
distant metastases based upon the following minimum diagnostic workup:
4. Zubrod Performance Status 0-1; 3.1.5 Age = 18; 3.1.6 CBC/differential obtained within
4 weeks prior to registration, with adequate bone marrow function 3.1.7 Adequate
renal and hepatic function within 4 weeks prior to registration 3.1.8 Negative serum
pregnancy test within 2 weeks prior to registration for women of childbearing
potential; 3.1.9 Women of childbearing potential and male participants who are
sexually active must practice adequate contraception during treatment and for 6 weeks
following treatment. 3.1.10 Patients must be deemed able to comply with the treatment
plan and follow-up schedule.
Exclusion Criteria:
3.2.1 Patients with residual macroscopic disease after surgery; 3.2.2 Patients with
salivary gland malignancies originating from the minor salivary glands; 3.2.3 Patients
with histologies other than high grade mucoepidermoid carcinoma, high grade adenocarcinoma
or salivary duct carcinoma; 3.2.4 Prior invasive malignancy (except non-melanomatous skin
cancer) unless disease free for a minimum of 3 years (for example, carcinoma in situ of
the breast, oral cavity, or cervix are all permissible); 3.2.5 Prior systemic chemotherapy
or radiation therapy for salivary gland malignancy; note that prior chemotherapy for a
different cancer is allowable; 3.2.6 Prior radiotherapy to the region of the study cancer
that would result in overlap of radiation therapy fields; 3.2.7 Severe, active
co-morbidity, defined as follows: 3.2.7.1 Unstable angina and/or congestive heart failure
requiring hospitalization within the last 6 months; 3.2.7.2 Transmural myocardial
infarction within the last 6 months; 3.2.7.3 Acute bacterial or fungal infection requiring
intravenous antibiotics at the time of registration; 3.2.7.4 Chronic Obstructive Pulmonary
Disease exacerbation or other respiratory illness requiring hospitalization or precluding
study therapy at the time of registration; 3.2.7.5 Hepatic insufficiency resulting in
clinical jaundice and/or coagulation defects; Note, however, coagulation parameters are
not required for entry into this protocol. 3.2.7.6 Acquired Immune Deficiency Syndrome
(AIDS) 3.2.7.7 Pre-existing = grade 2 neuropathy; 3.2.7.8 Prior organ transplant. 3.2.8
Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to use medically acceptable forms of contraception; this exclusion is
necessary; 3.2.9 Significant pre-existing hearing loss, as defined by the patient or
treating physician.
Age minimum:
18 Years
Age maximum:
80 Years
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Malignant Salivary Gland Tumors
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Intervention(s)
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Radiation: Radiation: 60-66 Gy in 2 Gy daily fractions
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Drug: Cisplatin: 40 mg/m2 weekly during radiation
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Primary Outcome(s)
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Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin.
[Time Frame: Two years]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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