Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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11 April 2016 |
Main ID: |
NCT01455025 |
Date of registration:
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24/06/2011 |
Prospective Registration:
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Yes |
Primary sponsor: |
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Public title:
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Study in Plerixafor and Granulocyte-colony Stimulating Factor Patients With Relapse Acute Myeloid Leukemia
PRIMAL |
Scientific title:
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A Phase 1, Dose Escalation Study of Plerixafor in Combination With Induction and Consolidation Chemotherapy in Patients With Relapsed Acute Myeloid Leukemia |
Date of first enrolment:
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January 2012 |
Target sample size:
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11 |
Recruitment status: |
Terminated |
URL:
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https://clinicaltrials.gov/show/NCT01455025 |
Study type:
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Interventional |
Study design:
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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Phase:
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Phase 1
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Countries of recruitment
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France
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Contacts
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Name:
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Didier BOUSCARY, MD PD |
Address:
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Telephone:
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Email:
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Affiliation:
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French Innovative Leukemia Organisation |
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Name:
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Xavier THOMAS, MD PD |
Address:
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Telephone:
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Email:
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Affiliation:
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ALFA |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Patients with Acute Myeloid Leukemia in first relapse with first response duration >
9 months.
- Age between 18 and 65 years.
- Treatment with hydroxyurea or purinethol is allowed if discontinued at least 24 hours
before the start of study treatment.
- White blood count less than 30 x 109/L
- Left ventricular ejection fraction more than 50% on echocardiography or multigated
acquisition scan or similar radionuclide angiographic scan.
- Total bilirubin less than 1.5 x upper limit of normal= ULN or AST and ALT less than
2.5 x ULN or gammaGT less than 2.5 x ULN.
- Serum creatinine less than 1.5 x ULN and/or creatinine clearance more than 50 ml/mn.
- ECOG performance status less than 2
- Absence of any psychological, familial, sociological or geographical condition
potentially hampering compliance with the study protocol and follow-up schedule.
- Absence of pregnancy or lactation
- Affiliated to French social security system or similar
- Signed informed consent
Exclusion Criteria:
- AML evolving from MPD and/or secondary AML
- Patients treated with more than 270 mg/m2 of daunorubicin during first line therapy.
- Have any of the following within the last 9 months :
- Unstable supraventricular arrhythmia or patient with a pace-maker
- Any ventricular arrhythmia
- Congestive heart failure
- Myocardial infarction, ischemia, stable coronary disease or angina pectoris
- Syncope with a known cardiovascular etiology
- Known hypersensitivity or contra-indication to drugs used in the protocol = G-CSF,
daunorubicin, cytarabine or to excipients.
- Previous treatment with plerixafor.
- Previous hematopoietic stem cell transplantation = Allologous or autologous.
- White blood count more than 30 x 109/L despite treatment with hydroxyurea or
purinethol.
- Treatment with chemotherapy or G-CSF within 3 months of screening.
- Uncontrolled active infection.
- Uncontrolled arrythmia
- Grade more than 3 renal dysfunction with serum creatinine more than 1.5 x ULN and/or
creatinine clearance less than 50 ml/mn.
- Significant neurologic grade more than 2 or psychiatric disorder, dementia or
seizures.
- Clinical symptoms suggesting active central nervous system leukemia.
- Pre-existing disorder predisposing the patient to serious or life-threatening
infections = cystic fibrosis, congenital or acquired immunodeficiency, bleeding
disorder or cytopenia
- Thrombocytopenia refractory to platelet transfusion
- Anticoagulant therapy
- Severe complications of leukemia such as uncontrolled bleeding, pneumonia with
hypoxia or shock or disseminated intravascular coagulation.
- Thrombocytopenia refractory to platelet transfusion.
- Prior total body irradiation more than 10 Gy.
- Known HIV, Hepatitis B or C positivity.
- Participation into a clinical study of an investigational agent within 14 days before
study entry.
- Pregnancy or breastfeeding
- Adult patient protected by law
- Concurrent treatment with any other anti-cancer therapy except hydroxyurea
Age minimum:
18 Years
Age maximum:
65 Years
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Acute Myeloid Leukemia
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Intervention(s)
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Drug: Plerixafor granulocyte-colony stimulating factor
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Primary Outcome(s)
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maximal tolerated dose
[Time Frame: 40 days]
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Secondary Outcome(s)
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Efficacy of combination plerixafor with granulocyte-colony stimulating factor, Daunorubicin and Cytarabine
[Time Frame: 2 months]
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safety and tolerability of plerixafor in combination with granulocyte-colony stimulating factor and chemotherapy
[Time Frame: 9 months]
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Efficacy of combination plerixafor with granulocyte-colony stimulating factor, Daunorubicin and Cytarabine
[Time Frame: 3 months]
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Efficacy of combination plerixafor with granulocyte-colony stimulating factor, Daunorubicin and Cytarabine
[Time Frame: 9 months]
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Efficacy of combination plerixafor with granulocyte-colony stimulating factor, Daunorubicin and Cytarabine
[Time Frame: 5 weeks]
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Efficacy of plerixafor on leukemic blasts
[Time Frame: 10 Days]
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Secondary ID(s)
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Primal study
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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