Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT01439399
• Date of registration: 20/09/2011
• Prospective Registration: No
• Primary sponsor: University of Lausanne Hospitals
• Public title: Analgesic Efficacy of Intravenous Lidocaine and/or Ketamine
• Scientific title: Analgesic Efficacy of Intravenous Perfusion of Lidocaine, Ketamine or a Combination After Laparotomy in a Placebo-controlled, Randomized, Double-blind Prospective Study
• Date of first enrolment: December 2005
• Target sample size: 52
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT01439399
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
• Phase: N/A

Countries of recruitment

Switzerland

Contacts

• Name: Christian Kern
• Affiliation: University of Lausanne Hospitals

Key inclusion & exclusion criteria

Inclusion Criteria:

- abdominal surgery by laparotomy

Exclusion Criteria:

- laparoscopy

- history of chronic pain

- opioid self-administration

- psychiatric disorders

- difficulties with communication

- renal or hepatic dysfunction

- ASA physical status > 3



Age minimum: 20 Years
Age maximum: 75 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Postoperative Pain

Intervention(s)

Drug: association ketamine-lidocaine

Drug: Ketamine

Drug: Lidocaine,

Drug: Placebo

Primary Outcome(s)

Cumulative morphine consumption [Time Frame: 48 hours]

Secondary Outcome(s)

Occurrence of side effects [Time Frame: 48 hours]

Pain scores [Time Frame: 48 hours]

Mechanical hyperalgesia [Time Frame: 48 hours]

Secondary ID(s)

179/05

KL-48h

Source(s) of Monetary Support

Please refer to primary and secondary sponsors