An Open-labeled Trial of Ramipril in Patients With Migraine

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT01402479
• Date of registration: 24/07/2011
• Prospective Registration: No
• Primary sponsor: Seoul National University Hospital
• Public title: An Open-labeled Trial of Ramipril in Patients With Migraine
• Scientific title: An Open-labeled Trial of Ramipril in Patients With Migraine
• Date of first enrolment: October 2004
• Target sample size: 50
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT01402479
• Study type: Interventional
• Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
• Phase: Phase 2

Countries of recruitment

Korea, Republic of

Key inclusion & exclusion criteria

Inclusion Criteria:

- Patients with chronic migraine are included in this study. Migraineurs should be aged
20 to 70 years old with the ability to read and understand the self-report scales,
including the headache diary, used in this study.

Exclusion Criteria:

1. Medication overuse headache are excluded in this study.

2. Treatment with other ACEI or medication that may affect ARS

3. Treatment with migraine prophylactic medications or anti-hypertensive agents
including ß adrenergic receptor or calcium channel blockers

4. Past history of hepatic or renal dysfunction; an abnormal electrocardiography; a
psychiatric disorder; a history of substance abuse; pregnancy or lactation; use of
anti-psychotics, antidepressants, or anti-anxiety drugs.



Age minimum: 20 Years
Age maximum: 70 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Migraine With Hypertension

Intervention(s)

Drug: Ramipril

Primary Outcome(s)

headache frequency [Time Frame: 12 week]

Secondary ID(s)

0408-131-005

Source(s) of Monetary Support

Please refer to primary and secondary sponsors