Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT01228890
• Date of registration: 25/10/2010
• Prospective Registration: No
• Primary sponsor: University of Chicago
• Public title: Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT) CATCH-IT
• Scientific title: Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)
• Date of first enrolment: September 2010
• Target sample size: 0
• Recruitment status: Withdrawn
• URL: http://clinicaltrials.gov/show/NCT01228890
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment
• Phase: Phase 3

Countries of recruitment

United States

Contacts

• Name: Benjamin Van Voorhees, MD
• Affiliation: University of Chicago

Key inclusion & exclusion criteria

Inclusion Criteria:

- Youth ages 13 through 17.

- Youth must be experiencing elevated level of depressive symptoms on the Center for
Epidemiologic Studies Depression46 (CES-D) scale (score >/= 16) and have at least two
core symptoms of Major Depression on the Patient Health Questionnaire, Adolescents.

- Youth will be included if they have a past history of depression, anxiety,
externalizing symptoms, or substance abuse.

Exclusion Criteria:

- Current DSM-IV diagnosis (Kiddie Schedule of Affective Disorders) of Major Depressive
Disorder, current therapy for depression, or be taking antidepressants (e.g., SSRIs,
TCAs, MAOIs, bupropion, nefazodone, mirtazapine, venlafaxine).

- Current CES-D score >35

- DSM-IV diagnosis of schizophrenia (current or past) or bipolar affective disorder

- Current serious medical illness that causes significant disability or dysfunction

- Significant reading impairment (a minimum sixth-grade reading level based on parental
report), mental retardation, or developmental disabilities

- Serious imminent suicidal risk (as determined by endorsement of current suicidality
on CES-D or in KSADS interview) or other conditions that may require immediate
psychiatric hospitalization

- Psychotic features or disorders, or currently be receiving psychotropic medication

- Extreme, current drug/alcohol abuse (greater than or equal to 2 on the CRAFFT).



Age minimum: 13 Years
Age maximum: 17 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Externalizing Symptoms

Substance Abuse

Anxiety

Depression

Intervention(s)

Behavioral: CATCH-IT

Behavioral: AMPE

Primary Outcome(s)

To determine whether the CATCH-IT 2-R depression prevention intervention prevents or delays major depressive episodes, as well as non-affective disorder episodes, compared to AMPE. [Time Frame: 49-60 months from beginning of trial]

Secondary Outcome(s)

To determine if participants in the CATCH-IT 2-R program report lower perceived educational impairment, greater quality of life, greater health-related quality of life, and lower incidence of other mental disorders (anxiety, substance/alcohol use). [Time Frame: 49-60 months from beginning of trial]

To determine if participants in the CATCH-IT 2-R group exhibit more rapid favorable changes of depressive symptoms/and or vulnerability/protective factors compared with the AMPE group. [Time Frame: 49-60 months from beginning of the trial]

To determine for whom (moderators) and how (mediators) the CATCH-IT 2-R program works in this population. [Time Frame: 49-60 months from beginning of trial]

Secondary ID(s)

10-464-A

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Harvard Vanguard Medical Associates