Primary Outcome(s)
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 21]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 22]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 3]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 20]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 1]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 11]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 23]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 3]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 10]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 15]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 4]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 5]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 7]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 12]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 13]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 19]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 10]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 8]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 11]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 9]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 5]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 6]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 1]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 9]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 19]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 14]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 12]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 21]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 16]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 17]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 7]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 17]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 20]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 8]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 23]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 22]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 2]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 4]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 16]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 18]
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Pharmacodynamics measured by maximum international normalised ratio ( INRmax)
[Time Frame: International normalised ratio (INR) sampling will be performed day 2]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 13]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 14]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 15]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 18]
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Pharmacokinetics for (R)- and (S)- Warfarin, measured by maximum plasma concentration (Cmax ) and area under the plasma concentration-time curve (AUC)
[Time Frame: Pharmacokinetic (PK) sampling will be performed day 6]
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