Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT01025245
• Date of registration: 27/11/2009
• Prospective Registration: No
• Primary sponsor: Yonsei University
• Public title: Effect of Intraoperative Magnesium on Remifentanil-induced Postoperative Hyperalgesia After Thyroidectomy
• Date of first enrolment: November 2009
• Target sample size: 84
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT01025245
• Study type: Interventional
• Study design: Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
• Phase: Phase 4

Countries of recruitment

Korea, Republic of

Key inclusion & exclusion criteria

Inclusion Criteria:

- Patients undergoing thyroidectomy,

- Age 20-65,

- American Society of Anesthesiologists physical status classification I or II.

Exclusion Criteria:

- History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive
drugs,

- History of drug & alcohol abuse,

- Psychiatric disorder,

- Use of opioids within 24hrs,

- Renal disease with decreased GFR,

- Neuromuscular disease, Severe cardiac disease.



Age minimum: 20 Years
Age maximum: 65 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Hyperalgesia

Intervention(s)

Drug: remifentanil, MgSO4

Primary Outcome(s)

Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs [Time Frame: postoperative 48 hrs]

Secondary ID(s)

4-2009-0511

Source(s) of Monetary Support

Please refer to primary and secondary sponsors