Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT00819442
• Date of registration: 08/01/2009
• Prospective Registration: No
• Primary sponsor: Ministry of Scientific Research and Information Technology, Poland
• Public title: Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis DESMIN
• Scientific title: Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis.
• Date of first enrolment: January 2009
• Target sample size: 60
• Recruitment status: Not yet recruiting
• URL: http://clinicaltrials.gov/show/NCT00819442
• Study type: Interventional
• Study design: Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
• Phase: N/A

Countries of recruitment

Poland

Contacts

• Name: Agnieszka Pawlak, PhD

Key inclusion & exclusion criteria

Inclusion Criteria:

- idiopatic dilated cardiomyopathy, NYHA I, II, III, IV

- dilated left ventricle

- ejection fraction below 45%

Exclusion Criteria:

- diabetes mellitus

- kidney failure (GFR < 30, creatinine below 2,5 mg/dl



Age minimum: 18 Years
Age maximum: 65 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Dilated Cardiomyopathy

Intervention(s)

Procedure: cardiobiopsy

Primary Outcome(s)

all cause mortality [Time Frame: one year]

Secondary Outcome(s)

qualitative differences in desmin expression in cardiomyocytes of patient with heart failure [Time Frame: one year]

Secondary ID(s)

N N402196135

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Polish Academy of Sciences