Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT00647088
• Date of registration: 26/03/2008
• Prospective Registration: No
• Primary sponsor: Assistance Publique - Hôpitaux de Paris
• Public title: Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications GENERAC
• Scientific title: Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications
• Date of first enrolment: March 2008
• Target sample size: 2200
• Recruitment status: Recruiting
• URL: https://clinicaltrials.gov/show/NCT00647088
• Study type: Observational
• Phase: N/A

Countries of recruitment

France

Contacts

• Name: David MESSIKA-ZEITOUN, MD

• Name: David Messika-Zeitoun, MD
• Affiliation: Assistance Publique - Hôpitaux de Paris

Key inclusion & exclusion criteria

Patients:

Inclusion criteria :

- Age >=18 years

- Pure isolated degenerative aortic valve stenosis

Exclusion criteria :

- Rheumatic, congenital or post-radiation aortic stenosis

- Severe renal insufficiency (clearance < 30 ml/min)

- Aortic insufficiency > or = grade 2/4

- Other valve disease > or = grade 2/4

Controls

Inclusion criteria :

- Age >=18 years

Exclusion criteria :

- Known first degree relative with aortic valve stenosis

- Severe renal insufficiency (clearance < 30 ml/min)

- Any valve disease > or = grade 2/4



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Aortic Valve Stenosis

Primary Outcome(s)

Identification of genetic polymorphisms of fetuin-A, matrix-GLA protein, vitamin D receptor [Time Frame: end of the study]

Secondary Outcome(s)

Identification of other genetic polymorphisms [Time Frame: End of the Study]

Secondary ID(s)

P070141

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Institut National de la Santé Et de la Recherche Médicale, France