Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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3 August 2015 |
Main ID: |
NCT00420888 |
Date of registration:
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09/01/2007 |
Prospective Registration:
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No |
Primary sponsor: |
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Public title:
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ABR-217620/Naptumomab Estafenatox With Interferon-alpha (IFN-alpha) Compared to IFN-alpha Alone in Patients With Advanced Renal Cell Carcinoma
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Scientific title:
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A Randomized, Open-label, Multi-center, Phase II/III Study on Treatment With ABR-217620/Naptumomab Estafenatox Combined With IFN-alpha vs. IFN-alpha Alone in Patients With Advanced Renal Cell Carcinoma. |
Date of first enrolment:
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January 2007 |
Target sample size:
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526 |
Recruitment status: |
Completed |
URL:
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https://clinicaltrials.gov/show/NCT00420888 |
Study type:
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Interventional |
Study design:
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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Phase:
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Phase 2/Phase 3
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Countries of recruitment
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Bulgaria
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Norway
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Romania
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Russian Federation
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Ukraine
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United Kingdom
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Contacts
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Name:
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Thore Nederman, PhD |
Address:
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Telephone:
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Email:
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Affiliation:
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Active Biotech AB |
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- Histologically or cytologically confirmed RCC (clear cell and papillary types)
- Metastatic or inoperable locally advanced RCC
- Eligible for therapy with IFN-alpha.
- Measurable disease defined by at least 1 measurable lesion on CT scan (lesion
diameter greater than or equal to 2.0 cm by a standard CT scanner or greater than or
equal to 1.0 cm by a spiral CT scanner)
- Favorable or moderate risk group prognosis by MSKCC (Motzer) criteria (score 0-2)
- Karnofsky performance status greater than or equal to 70
- Age greater than or equal to 18
- Life expectancy greater than 3 months
- Baseline blood counts:
- Absolute neutrophil count (ANC) greater than or equal to 1.5 x 10^9/L
- Platelets greater than or equal to 100 x 10^9/L
- Haemoglobin greater than or equal to 100 g/L
- Baseline blood chemistry levels:
- Creatinine less than or equal to 1.5 x upper limit of normal (ULN)
- Bilirubin less than or equal to 2 x ULN
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or
equal to 2.5 x ULN. AST and ALT allowed less than or equal to 5 x ULN for
patients with liver metastases.
- If fertile, patient will use effective method of contraception throughout the study
- Willing and able to comply with the treatment and follow-up visits and examinations
- Capable of understanding the parameters in the protocol and able to sign a written
consent form
Exclusion Criteria:
- Pregnant or breastfeeding women
- Serious uncontrolled medical disorder or active infection ongoing or resolved within
2 weeks before first dose of study drug and that the investigator believes would
impair the patient's ability to receive study drug
- History of malignancy within 5 years or concurrent malignancy, except successfully
treated non-melanoma skin cancer, cervical cancer in situ, ductal carcinoma in situ
or lobular carcinoma in situ of breast may be included
- History and/or signs of parenchymal brain metastases
- Significant cardiac disease including: history (within 6 months) or current unstable
angina pectoris, congestive heart failure (NYHA stage III-IV), myocardial infarction
within 12 months, or uncontrolled arterial hypertension.
- History of stroke within 5 years and/or transient ischemic attack within 6 months.
- Acute illness or evidence of infection, including unexplained fever (>100.5ºF or
38.1ºC) within 2 weeks before start of treatment
- Treatment with biological response modifiers within 3 weeks prior to the start of
treatment and up to the End-of-Study visit
- Treatment with beta-blockers, including topical therapy for glaucoma, within 5 days
before start of treatment and during the 4-day ABR-217620/naptumomab estafenatox
treatment
- Treatment with systemic corticosteroids within 2 weeks before start of treatment or
likely need for such treatment during the study
- Active autoimmune disease requiring therapy or any history of systemic lupus
erythematosus or rheumatoid arthritis
- Known positive serology for HIV
- Chronic hepatitis with advanced, decompensated hepatic disease or cirrhosis of the
liver or history of chronic virus hepatitis or known virus carrying; patients who
recovered from Hepatitis A are allowed
- Treatment with anticoagulants within 2 weeks before start of treatment, except when
used to maintain the patency of a central or peripheral venous line
- Radiotherapy less than 4 weeks before start of treatment
- Major surgery or tumor embolization less than 4 weeks before start of treatment
- Previous exposure to murine monoclonal antibodies or known hypersensitivity to murine
proteins
- Currently on renal dialysis treatment
- Known allergy or hypersensitivity to aminoglycosides and kanamycin
- Previous systemic anti-tumor therapy for RCC (including immunotherapy with IFN-alpha
or IL-2 or any chemotherapy) except sunitinib or other oral antiangiogenic therapy
- Participation in any study with investigational drugs for RCC within 6 weeks
Age minimum:
18 Years
Age maximum:
N/A
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Renal Cell Carcinoma
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Intervention(s)
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Drug: ABR-217620/naptumomab estafenatox
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Drug: IFN-alpha
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Primary Outcome(s)
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Time to death
[Time Frame: every 12 weeks, including after a maximum of 18 months of study treatment]
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Secondary Outcome(s)
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Objective tumor response rate
[Time Frame: every 12 weeks for the 18-month treatment period]
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Immunological response in patients on combined treatment of ABR-217620/naptumomab estafenatox and IFN-alpha
[Time Frame: Weeks 1, 9, 17, 25, 73]
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Pharmacokinetic parameters of ABR-217620/naptumomab estafenatox
[Time Frame: Weeks 1, 9, and 17]
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Progression-free survival time
[Time Frame: every 12 weeks for the 18-month treatment period and also every 12 weeks after the treatment period]
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Changes in sum of target lesions
[Time Frame: every 12 weeks for the 18-month treatment period]
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Vital signs
[Time Frame: every visit through Week 25, plus Week 73]
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Best overall response
[Time Frame: every 12 weeks for the 18-month treatment period]
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Physical measurements
[Time Frame: Weeks 1, 9, 17, 25, 73]
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Duration of response
[Time Frame: every 12 weeks for the 18-month treatment period]
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Laboratory safety assessments
[Time Frame: Weeks 1, 2, 3, 5, 9, 10, 13, 17, 18, 21, 25, and 73]
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Adverse events
[Time Frame: every visit through Week 73]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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