Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease

• Register: ClinicalTrials.gov
• Last refreshed on: 8 June 2015
• Main ID: NCT00380185
• Date of registration: 22/09/2006
• Prospective Registration: No
• Primary sponsor: Stanford University
• Public title: Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease GenePAD
• Scientific title: The Genetic Determinants of Peripheral Arterial Disease
• Date of first enrolment: April 2004
• Target sample size: 1789
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00380185
• Study type: Observational
• Study design: Observational Model: Case Control, Time Perspective: Prospective
• Phase: N/A

Countries of recruitment

United States

Contacts

• Name: John P. Cooke, MD, PhD
• Affiliation: Stanford University

Key inclusion & exclusion criteria

Inclusion Criteria:

- Hemodynamically significant PAD, as documented by an ankle-brachial index less than
0.9; control group participants will not have PAD

- Received a referral for an elective coronary angiogram

- Suspected CAD

Exclusion Criteria:

- History of radiation treatment

- History of organ transplant

- History of viral diseases (i.e. HIV, hepatitis)



Age minimum: 40 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Peripheral Vascular Diseases

Primary Outcome(s)

Identifying genetic variations that may cause inherited differences in plaque distribution [Time Frame: Measured at participants' study visit]

Secondary ID(s)

R01HL075774

1361

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

National Heart, Lung, and Blood Institute (NHLBI)