The Effects of Increased Central Serotonergic Activity on Information Processing

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT00206934
• Date of registration: 12/09/2005
• Prospective Registration: No
• Primary sponsor: University of Copenhagen
• Public title: The Effects of Increased Central Serotonergic Activity on Information Processing
• Scientific title: The Effects of Increased Central Serotonergic Activity on Psychophysiological Parameters of Human Information Processing
• Date of first enrolment: March 2005
• Target sample size: 40
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00206934
• Study type: Interventional
• Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Diagnostic
• Phase: N/A

Countries of recruitment

Denmark

Contacts

• Name: Birte Glenthoj, MD, DMSc.
• Affiliation: Center for Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychaitric Center Glostrup, Ndr. Ringvej, DK-2600 Glostrup, Denmark

Key inclusion & exclusion criteria

Inclusion Criteria:

- Male subjects

- Good Physical and Mental Health meeting criteria "never mentally ill", which will be
evaluated with a medical history checklist, ECG

- Non smokers

Exclusion Criteria:

- Current use of any medication

- Any subject who has received any investigational medication within 30 days prior to
the start of this study

- History of neurologic illness

- History of psychiatric illness in first-degree relatives, evaluated with DSM-IV
criteria

- History of alcohol and drug abuse. Positive urine screening for amphetamine, cocaine,
cannabis, or esctacy.



Age minimum: 18 Years
Age maximum: 35 Years
Gender: Male

Health Condition(s) or Problem(s) studied

Healthy Volunteers

Intervention(s)

Drug: Escitalopram

Drug: escitaolpram

Primary Outcome(s)

The mismatch negativity (MMN) task [Time Frame: Once, 3.5 hrs after intake of capsule]

The P300 ERP task [Time Frame: Once, 3.5 hrs after intake of capsule]

The P50 Suppression task [Time Frame: Once, 3.5 hrs after intake of capsule]

The PPI (Prepulse Inhibition of the Startle Response) task [Time Frame: Once, 3.5 hrs after intake of capsule]

Secondary ID(s)

363037-1

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Glostrup University Hospital, Copenhagen

Lundbeck Foundation