Loxapine and Weaning From Ventilator

• Register: ClinicalTrials.gov
• Last refreshed on: 19 February 2015
• Main ID: NCT00122733
• Date of registration: 19/07/2005
• Prospective Registration: Yes
• Primary sponsor: Assistance Publique - Hôpitaux de Paris
• Public title: Loxapine and Weaning From Ventilator
• Scientific title: Facilitation of Weaning From Ventilator by Loxapine
• Date of first enrolment: December 2005
• Target sample size: 9
• Recruitment status: Completed
• URL: http://clinicaltrials.gov/show/NCT00122733
• Study type: Interventional
• Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
• Phase: N/A

Countries of recruitment

France

Contacts

• Name: Guillaume CHEVREL, MD
• Affiliation: Assistance Publique - Hôpitaux de Paris

Key inclusion & exclusion criteria

Inclusion Criteria:

- Patients who are eligible for weaning from the respirator (FIO2 less than 50%;
positive end expiratory pressure [PEEP] level less than 6 cmH2O)

- Patients whose agitation (according to accepted scores) during a weaning trial
precludes extubation

Exclusion Criteria:

- History of convulsions or epilepsy



Age minimum: 18 Years
Age maximum: N/A
Gender: Both

Health Condition(s) or Problem(s) studied

Respiratory Insufficiency

Psychomotor Agitation

Intervention(s)

Drug: loxapine

Primary Outcome(s)

improvement in the clinical and biological parameters of weaning trial [Time Frame: 3 hours]

cessation of agitation [Time Frame: 3 hours]

Secondary ID(s)

LMR2

Source(s) of Monetary Support

Please refer to primary and secondary sponsors