Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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19 February 2015 |
Main ID: |
NCT00003031 |
Date of registration:
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01/11/1999 |
Prospective Registration:
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No |
Primary sponsor: |
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Public title:
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Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis
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Scientific title:
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An Open Randomised Comparative Multicentre Study of the Efficacy, Safety and Toleration of Voriconazole Versus Amphotericin-B in the Treatment of Acute Invasive Aspergillosis in Immunocompromised Patients |
Date of first enrolment:
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June 1997 |
Target sample size:
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212 |
Recruitment status: |
Completed |
URL:
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http://clinicaltrials.gov/show/NCT00003031 |
Study type:
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Interventional |
Study design:
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Allocation: Randomized, Primary Purpose: Supportive Care
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Phase:
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Phase 3
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Countries of recruitment
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Australia
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Belgium
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France
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Germany
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Hungary
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Ireland
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Israel
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Italy
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Luxembourg
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Netherlands
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Spain
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Sweden
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Switzerland
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United Kingdom
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United States
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Contacts
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Name:
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R. Herbrecht, MD |
Address:
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Telephone:
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Email:
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Affiliation:
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Hopital Universitaire Hautepierre |
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Key inclusion & exclusion criteria
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DISEASE CHARACTERISTICS: Patient immunocompromised as the result of any of the following:
Allogeneic bone marrow/peripheral stem cell transplant Autologous bone marrow/peripheral
stem cell transplant Hematological malignancy (including lymphoma) Aplastic anemia and
myelodysplastic syndromes (currently on immunosuppressive treatment) Solid organ
transplantation (other than lung) Other solid organ malignancy (after cytotoxic
chemotherapy) HIV/AIDS High dose prolonged corticosteroid therapy (at least 20 mg/day of
prednisolone or equivalent for more than 3 weeks) or prolonged therapy with other
immunosuppressive agents (e.g., azathioprine, methotrexate) Diagnosis of either definite
or probable acute invasive aspergillosis Fungal infection represents a new episode of
acute invasive aspergillosis Patients with the following are ineligible: Aspergilloma or
allergic bronchopulmonary aspergillosis Chronic invasive aspergillosis Sarcoidosis CMV
pneumonia
PATIENT CHARACTERISTICS: Age: 12 and over Life expectancy: At least 72 hours
Hematopoietic: Not specified Hepatic: Bilirubin no greater than 5 times upper limit of
normal (ULN) SGOT/SGPT no greater than 5 times ULN Alkaline phosphatase no greater than 5
times ULN Renal: Creatinine no greater than 2.5 mg/dL Other: No history of
hypersensitivity or intolerance to azole antifungal agents including miconazole,
ketoconazole, fluconazole, or itraconazole No history of hypersensitivity or severe
intolerance to conventional or lipid formulations of amphotericin B Not pregnant or
nursing Fertile women must use effective contraception Negative pregnancy test No prior
participation on this trial Not on artificial ventilation and unlikely to be extubated
within 24 hours No condition that could affect patient safety, preclude evaluation of
response, or make study completion unlikely
PRIOR CONCURRENT THERAPY: At least 8 weeks since prior systemic treatment with
amphotericin B or itraconazole At least 2 weeks since prior systemic antifungal therapy
for more than 96 hours at doses greater than 0.5 mg/kg/day for conventional or lipid
formulations of amphotericin B or greater than 200 mg/day of itraconazole No concurrent
drugs that are metabolized primarily by hepatic cytochrome P-450 enzymes or which induce
or inhibit these enzymes, such as terfenadine, loratidine, astemizole, midazolam,
triazolam, cisapride, rifampin, rifabutin, barbiturates, carbamazepine, coumarins,
sulfonylureas, nivarapine, erythromycin, ritonavir, delaviridine, omeprazole, and
phenytoin At least 2 weeks since prior rifampin, rifabutin, carbamazepine, or barbiturates
for more than 3 days No concurrent investigational drugs other than cytotoxics,
antiretroviral agents, or therapies for AIDS-related opportunistic infection No concurrent
filgrastim (G-CSF) or sargramostim (GM-CSF) other than for treatment of granulocytopenia
No concurrent white blood cell transfusions No concurrent systemic antifungal agents
active against Aspergillus spp. (e.g., itraconazole, lipid formulations of amphotericin B,
or flucytosine)
Age minimum:
12 Years
Age maximum:
N/A
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Pulmonary Complications
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Infection
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Intervention(s)
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Drug: voriconazole
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Drug: amphotericin B deoxycholate
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Secondary ID(s)
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PFIZER-150-307-000
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EORTC-19961
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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