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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ISRCTN |
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Last refreshed on:
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25 November 2019 |
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Main ID: |
ISRCTN74298211 |
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Date of registration:
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28/02/2001 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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A trial comparing conventional fractionation with 'CHART' in the radical treatment of non-small cell carcinoma of the bronchus
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Scientific title:
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A trial comparing conventional fractionation with 'CHART' in the radical treatment of non-small cell carcinoma of the bronchus |
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Date of first enrolment:
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01/02/1990 |
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Target sample size:
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600 |
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Recruitment status: |
Completed |
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URL:
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http://isrctn.com/ISRCTN74298211 |
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Study type:
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Interventional |
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Study design:
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Randomised controlled trial (Not Specified)
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Phase:
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Not Specified
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Countries of recruitment
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United Kingdom
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Contacts
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Name:
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Address:
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Telephone:
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Email:
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Affiliation:
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Name:
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James
Lyddiard |
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Address:
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MRC Clinical Trials Unit
222 Euston Road
NW1 2DA
London
United Kingdom |
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Telephone:
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- |
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Email:
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abc@email.com |
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Affiliation:
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Key inclusion & exclusion criteria
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Inclusion criteria: Inoperable non-small cell carcinoma of the bronchus confined to the thorax proven by histology or by unequivocal brush cytology
Exclusion criteria:
1. There should be no evidence of distant metastases including supraclavicular nodes;
2. The patient must have no evidence of a pleural effusion unless it can be attributed to a recent surgical intervention;
3. The volume of the site of tumour within the thorax should be such that a radical course of radiotherapy could be given without prejudicing vital structures such as the spinal cord or lung
Age minimum:
Age maximum:
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Cancer
Cancer
Non-small cell carcinoma of the bronchus
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Intervention(s)
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1. Conventional radiotherapy arm - 2 Gy, once daily five days a week over six weeks (large volume - 44 Gy in 22 fractions followed by small volume - 16 Gy in eight fractions)
2. CHART arm - 1.5 Gy, three time daily over 12 treatment days (large volume - 37.5 Gy in 25 fractions followed by small volume - 16.5 Gy in 11 fractions)
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Primary Outcome(s)
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Survival, Local tumour control, Morbidity
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Secondary Outcome(s)
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Not provided at time of registration
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Source(s) of Monetary Support
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Medical Research Council (MRC) (UK)
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Ethics review
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Status:
Approval date:
Contact:
Not provided at time of registration
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Results
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Results available:
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Yes |
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Date Posted:
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Date Completed:
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01/03/1995 |
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URL:
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