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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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EUCTR |
Last refreshed on:
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6 February 2017 |
Main ID: |
EUCTR2009-016203-32-ES |
Date of registration:
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20/10/2009 |
Prospective Registration:
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Yes |
Primary sponsor: |
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Public title:
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An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with immune (Idiopathic) Thrombocytopenia Purpura (ITP).------------------------------------------------
Estudio Abierto para Evaluar la Seguridad y Eficacia del Tratamiento a Largo Plazo con Romiplostim en Sujetos Pediátricos Trombocitopénicos con Púrpura Trombocitopénica Inmune (Idiopática) (PTI).
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Scientific title:
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An Open Label Study Evaluating the Safety and Efficacy of Long-Term Dosing of Romiplostim in Thrombocytopenic Pediatric Subjects with immune (Idiopathic) Thrombocytopenia Purpura (ITP).------------------------------------------------
Estudio Abierto para Evaluar la Seguridad y Eficacia del Tratamiento a Largo Plazo con Romiplostim en Sujetos Pediátricos Trombocitopénicos con Púrpura Trombocitopénica Inmune (Idiopática) (PTI). |
Date of first enrolment:
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19/11/2009 |
Target sample size:
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20 |
Recruitment status: |
Not Recruiting |
URL:
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https://www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2009-016203-32 |
Study type:
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Interventional clinical trial of medicinal product |
Study design:
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Controlled: yes
Randomised: no
Open: yes
Single blind: no
Double blind: no
Parallel group: no
Cross over: no
Other: yes
Other trial design description: NA
If controlled, specify comparator, Other Medicinial Product: no
Placebo: no
Other: no
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Phase:
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Human pharmacology (Phase I): no
Therapeutic exploratory (Phase II): no
Therapeutic confirmatory - (Phase III): yes
Therapeutic use (Phase IV): no
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Countries of recruitment
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Spain
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Key inclusion & exclusion criteria
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Inclusion criteria: Ethical - Subject or subject's legally acceptable representative has provided informed consent. Demographic - Subject is less than 18 years old at time of screening. Disease-Related - Subject completed a romiplostim study for the treatment of thrombocytopenia in pediatric subjects with ITP. Are the trial subjects under 18? yes Number of subjects for this age range: F.1.2 Adults (18-64 years) no F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria: Disease Related - Subject has or previously had any bone marrow stem cell disorder (any abnormal bone marrow findings other than those typical of ITP must be approved by Amgen before a subject may be enrolled in the study). - Subject has any new active malignancy diagnosed since enrollment in the previous romiplostim ITP study. Medications - Subject received any alkylating agents within four weeks before the screening visit or anticipated use during the time of the proposed study. General - Other investigational medications are excluded. - Currently enrolled in another investigational device or drug study, or less than 30 days since ending another investigational device or drug study(s), or receiving other investigational agent(s). - Subject (male or female) is not willing to use highly effective contraception during treatment if and when sexually active and for 4 weeks (women) or 14 weeks (men) after the end of treatment. - Subject is pregnant or breast feeding, or planning to become pregnant within 4 weeks after the end of treatment. - Male subject with a pregnant partner who is not willing to use a condom if and when sexually active during treatment and for 14 weeks after the end of treatment. - Subject has known sensitivity to any of the products to be administered during dosing. - Subject previously has entered this study (this will depend on the type of study). - Subject will not be available for protocol-required study visits, to the best of the subject and investigator?s knowledge. - Subject has any kind of disorder that, in the opinion of the investigator, may compromise the ability of the subject to give written informed consent and/or to comply with all required study procedures.
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Age maximum:
Gender:
Female: yes Male: yes
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Health Condition(s) or Problem(s) studied
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Thrombocytopenia in pediatric subjects with ITP---------Sujetos Pediátricos Trombocitopénicos con Púrpura Trombocitopénica Inmune (Idiopática) (PTI) MedDRA version: 12.0
Level: LLT
Classification code 10043558
Term: Thrombocytopenia purpura
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Intervention(s)
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Product Name: NPLATE Pharmaceutical Form: Powder for solution for injection INN or Proposed INN: ROMIPLOSTIM Other descriptive name: ROMIPLOSTIM Concentration unit: mg/ml milligram(s)/millilitre Concentration type: equal Concentration number: 0.5-
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Primary Outcome(s)
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Main Objective: The primary objective of this study is to evaluate the safety of romiplostim as a long-term treatment in pediatric thrombocytopenic subjects with immune (idiopathic) thrombocytopenic purpura (ITP).
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Secondary Objective: This study will also evaluate the long-term platelet response to romiplostim as well as the possible reductions in the dose of concurrent ITP therapies while receiving romiplostim.
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Primary end point(s): The primary endpoints are the subject incidence and exposure adjusted incidence of adverse events, including clinically significant changes in laboratory values and incidence of antibody formation.
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Results
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Results available:
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