Clinical observation of MPA and HMG used for controlled ovarian stimulation in patients with diminshed ovarian reserve

• Register: ChiCTR
• Last refreshed on: 18 April 2017
• Main ID: ChiCTR-OCH-14004176
• Date of registration: 2014-01-07
• Prospective Registration: Yes
• Primary sponsor: Shanghai Ninth People's Hospital
• Public title: Clinical observation of MPA and HMG used for controlled ovarian stimulation in patients with diminshed ovarian reserve
• Scientific title: Clinical observation of MPA and HMG used for controlled ovarian stimulation in patients with diminsh
• Date of first enrolment: 2014-01-08
• Target sample size: MPA group:91;control:91;
• Recruitment status: Completed
• URL: http://www.chictr.org.cn/showproj.aspx?proj=5392
• Study type: Observational study
• Study design: Cohort study
• Phase: IV (Phase IV study)

Countries of recruitment

China

Contacts

• Name: Chen Qiuju
• Affiliation: Shanghai Nineth People's Hospital

• Name: Kuang Yanping
• Affiliation: Shanghai Nineth People's Hospital

Key inclusion & exclusion criteria

Inclusion criteria: 1) aged 25–45 years;
2) have a spontaneous menstrual cycle (21–35 days in duration);
3) antral follicle counts (AFC) < 5 on menstrual cycle day 3 or a basal serum FSH concentration between10–30mIU/ml;
4) no functional cysts present on the bilateral ovaries on menstrual cycle day 3.
Exclusion criteria: 1) clinically significant systemic disease such as renal failure;
2) documented ovarian failure;
3) any contraindications to ovarian stimulation treatment.

Age minimum: 25
Age maximum: 45
Gender: Female

Health Condition(s) or Problem(s) studied

infertility

Intervention(s)

MPA group:MPA and HMG;control:natural cycle ;

Primary Outcome(s)

incidence of LH surge; incidence of advanced ovulation;

Secondary Outcome(s)

the number of mature oocyte;the number of fertilized oocytes;the number of cleavaged embryo;

Source(s) of Monetary Support

national natural science foundation